Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes
Joint Authors
Le Souëf, Peter N.
Goldblatt, Jack
Zhang, Guicheng
Holt, Patrick
Hayden, Catherine M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The expression of allergic phenotypes involves complex inter-relationships among several Th2 and Th1 cytokines as well as the regulator cytokine interleukin (IL)-10.
These direct or indirect interrelationships may distort the true associations of cytokine responses with these phenotypes.
In this study, we aimed to clarify the effects of the regulatory cytokine IL-10 and Th1 cytokine interferon-gamma (IFN-γ) on allergic phenotypes after adjusting for the correlations with Th2 cytokines.
After adjusting for Th2 cytokines, IL-10 and IFN-γ were protective against atopy.
Adjusted levels of IL-10 and IFN-γ stimulated with house-dust mite (HDM) were significantly lower in atopics than non-atopics, for IL-10 adjusting for IL-5 (P=0.002), IL-13 (P=0.012), IL-9 (P=0.016), and IL-4 (P=0.043), and for IFN-γ adjusting for IL-5 (P=0.005), IL-13 (P=0.005), and IL-9 (P=0.037).
IL-10 and IFN-γ levels stimulated with phytohaemagglutinin (PHA) and staphylococcal enterotoxin B (SEB) exhibited a similar pattern.
The adjusted levels of IL-10 and IFN-γ stimulated with HDM, PHA or SEB were all significantly negatively correlated with total serum IgE, except for IFN-γ stimulated with SEB.
Levels of Th2 cytokines distort the associations of IL-10 and IFN-γ with allergic phenotypes.
Removing the covariance with Th2 cytokines, both IL-10 and IFN-γ were protective against atopy.
American Psychological Association (APA)
Zhang, Guicheng& Hayden, Catherine M.& Goldblatt, Jack& Holt, Patrick& Le Souëf, Peter N.. 2011. Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes. ISRN Allergy،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469507
Modern Language Association (MLA)
Zhang, Guicheng…[et al.]. Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes. ISRN Allergy No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-469507
American Medical Association (AMA)
Zhang, Guicheng& Hayden, Catherine M.& Goldblatt, Jack& Holt, Patrick& Le Souëf, Peter N.. Th2 Cytokine Levels Distort the Association of IL-10 and IFN-γ with Allergic Phenotypes. ISRN Allergy. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469507
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469507