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Molecular Regulation of Bone Marrow Metastasis in Prostate and Breast Cancer
Joint Authors
Ahmadzadeh, Ahmad
Shahjahani, Mohammad
Saki, Najmaldin
Shahrabi, Saeid
Mortaz, Esmaeil
Rahim, Fakher
Hajizamani, Saeideh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Metastasis is a multistep process, which refers to the ability to leave a primary tumor through circulation toward the distant tissue and form a secondary tumor.
Bone is a common site of metastasis, in which osteolytic and osteoblastic metastasis are observed.
Signaling pathways, chemokines, growth factors, adhesion molecules, and cellular interactions as well as miRNAs have been known to play an important role in the development of bone metastasis.
These factors provide an appropriate environment (soil) for growth and survival of metastatic tumor cells (seed) in bone marrow microenvironment.
Recognition of these factors and determination of their individual roles in the development of metastasis and disruption of cellular interactions can provide important therapeutic targets for treatment of these patients, which can also be used as prognostic and diagnostic biomarkers.
Thus, in this paper, we have attempted to highlight the molecular regulation of bone marrow metastasis in prostate and breast cancers.
American Psychological Association (APA)
Rahim, Fakher& Hajizamani, Saeideh& Mortaz, Esmaeil& Ahmadzadeh, Ahmad& Shahjahani, Mohammad& Shahrabi, Saeid…[et al.]. 2014. Molecular Regulation of Bone Marrow Metastasis in Prostate and Breast Cancer. Bone Marrow Research،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-469525
Modern Language Association (MLA)
Rahim, Fakher…[et al.]. Molecular Regulation of Bone Marrow Metastasis in Prostate and Breast Cancer. Bone Marrow Research No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-469525
American Medical Association (AMA)
Rahim, Fakher& Hajizamani, Saeideh& Mortaz, Esmaeil& Ahmadzadeh, Ahmad& Shahjahani, Mohammad& Shahrabi, Saeid…[et al.]. Molecular Regulation of Bone Marrow Metastasis in Prostate and Breast Cancer. Bone Marrow Research. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-469525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469525