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Embryonic Signaling Pathways and Rhabdomyosarcoma : Contributions to Cancer Development and Opportunities for Therapeutic Targeting
Joint Authors
Linardic, Corinne M.
Kirsch, David G.
Blum, Jordan
Belyea, Brian
Kephart, Julie Grondin
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence, accounting for approximately 7% of childhood cancers.
Current therapies include nonspecific cytotoxic chemotherapy regimens, radiation therapy, and surgery; however, these multimodality strategies are unsuccessful in the majority of patients with high-risk disease.
It is generally believed that these tumors represent arrested or aberrant skeletal muscle development, and, accordingly, developmental signaling pathways critical to myogenesis such as Notch, WNT, and Hedgehog may represent new therapeutic targets.
In this paper, we summarize the current preclinical studies linking these embryonic pathways to rhabdomyosarcoma tumorigenesis and provide support for the investigation of targeted therapies in this embryonic cancer.
American Psychological Association (APA)
Belyea, Brian& Kephart, Julie Grondin& Blum, Jordan& Kirsch, David G.& Linardic, Corinne M.. 2012. Embryonic Signaling Pathways and Rhabdomyosarcoma : Contributions to Cancer Development and Opportunities for Therapeutic Targeting. Sarcoma،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-469564
Modern Language Association (MLA)
Belyea, Brian…[et al.]. Embryonic Signaling Pathways and Rhabdomyosarcoma : Contributions to Cancer Development and Opportunities for Therapeutic Targeting. Sarcoma No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-469564
American Medical Association (AMA)
Belyea, Brian& Kephart, Julie Grondin& Blum, Jordan& Kirsch, David G.& Linardic, Corinne M.. Embryonic Signaling Pathways and Rhabdomyosarcoma : Contributions to Cancer Development and Opportunities for Therapeutic Targeting. Sarcoma. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-469564
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469564