Lineage Switching in Acute Leukemias : A Consequence of Stem Cell Plasticity?
Joint Authors
Pelayo, Rosana
Dorantes-Acosta, Elisa María
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-19
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Acute leukemias are the most common cancer in childhood and characterized by the uncontrolled production of hematopoietic precursor cells of the lymphoid or myeloid series within the bone marrow.
Even when a relatively high efficiency of therapeutic agents has increased the overall survival rates in the last years, factors such as cell lineage switching and the rise of mixed lineages at relapses often change the prognosis of the illness.
During lineage switching, conversions from lymphoblastic leukemia to myeloid leukemia, or vice versa, are recorded.
The central mechanisms involved in these phenomena remain undefined, but recent studies suggest that lineage commitment of plastic hematopoietic progenitors may be multidirectional and reversible upon specific signals provided by both intrinsic and environmental cues.
In this paper, we focus on the current knowledge about cell heterogeneity and the lineage switch resulting from leukemic cells plasticity.
A number of hypothetical mechanisms that may inspire changes in cell fate decisions are highlighted.
Understanding the plasticity of leukemia initiating cells might be fundamental to unravel the pathogenesis of lineage switch in acute leukemias and will illuminate the importance of a flexible hematopoietic development.
American Psychological Association (APA)
Dorantes-Acosta, Elisa María& Pelayo, Rosana. 2012. Lineage Switching in Acute Leukemias : A Consequence of Stem Cell Plasticity?. Bone Marrow Research،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-469614
Modern Language Association (MLA)
Dorantes-Acosta, Elisa María& Pelayo, Rosana. Lineage Switching in Acute Leukemias : A Consequence of Stem Cell Plasticity?. Bone Marrow Research No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-469614
American Medical Association (AMA)
Dorantes-Acosta, Elisa María& Pelayo, Rosana. Lineage Switching in Acute Leukemias : A Consequence of Stem Cell Plasticity?. Bone Marrow Research. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-469614
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469614