Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension
Joint Authors
Chrissobolis, Sophocles
Sobey, Christopher G.
Dinh, Quynh N.
Drummond, Grant R.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hypertension is a complex condition and is the most common cardiovascular risk factor, contributing to widespread morbidity and mortality.
Approximately 90% of hypertension cases are classified as essential hypertension, where the precise cause is unknown.
Hypertension is associated with inflammation; however, whether inflammation is a cause or effect of hypertension is not well understood.
The purpose of this review is to describe evidence from human and animal studies that inflammation leads to the development of hypertension, as well as the evidence for involvement of oxidative stress and endothelial dysfunction—both thought to be key steps in the development of hypertension.
Other potential proinflammatory conditions that contribute to hypertension—such as activation of the sympathetic nervous system, aging, and elevated aldosterone—are also discussed.
Finally, we consider the potential benefit of anti-inflammatory drugs and statins for antihypertensive therapy.
The evidence reviewed suggests that inflammation can lead to the development of hypertension and that oxidative stress and endothelial dysfunction are involved in the inflammatory cascade.
Aging and aldosterone may also both be involved in inflammation and hypertension.
Hence, in the absence of serious side effects, anti-inflammatory drugs could potentially be used to treat hypertension in the future.
American Psychological Association (APA)
Dinh, Quynh N.& Drummond, Grant R.& Sobey, Christopher G.& Chrissobolis, Sophocles. 2014. Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-469638
Modern Language Association (MLA)
Dinh, Quynh N.…[et al.]. Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-469638
American Medical Association (AMA)
Dinh, Quynh N.& Drummond, Grant R.& Sobey, Christopher G.& Chrissobolis, Sophocles. Roles of Inflammation, Oxidative Stress, and Vascular Dysfunction in Hypertension. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-469638
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469638