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IVIVC from Long Acting Olanzapine Microspheres
Joint Authors
Faraj, Jabar A.
Giovagnoli, Stefano
D'Souza, Susan
DeLuca, Patrick P.
Source
International Journal of Biomaterials
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-22
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In this study, four PLGA microsphere formulations of Olanzapine were characterized on the basis of their in vitro behavior at 37°C, using a dialysis based method, with the goal of obtaining an IVIVC.
In vivo profiles were determined by deconvolution (Nelson-Wagner method) and using fractional AUC.
The in vitro and in vivo release profiles exhibited the same rank order of drug release.
Further, in vivo profiles obtained with both approaches were nearly superimposable, suggesting that fractional AUC could be used as an alternative to the Nelson-Wagner method.
A comparison of drug release profiles for the four formulations revealed that the in vitro profile lagged slightly behind in vivo release, but the results were not statistically significant (P<0.0001).
Using the four formulations that exhibited different release rates, a Level A IVIVC was established using the deconvolution and fractional AUC approaches.
A nearly 1 : 1 correlation (R2>0.96) between in vitro release and in vivo measurements confirmed the excellent relationship between in vitro drug release and the amount of drug absorbed in vivo.
The results of this study suggest that proper selection of an in vitro method will greatly aid in establishing a Level A IVIVC for long acting injectables.
American Psychological Association (APA)
D'Souza, Susan& Faraj, Jabar A.& Giovagnoli, Stefano& DeLuca, Patrick P.. 2014. IVIVC from Long Acting Olanzapine Microspheres. International Journal of Biomaterials،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-469648
Modern Language Association (MLA)
D'Souza, Susan…[et al.]. IVIVC from Long Acting Olanzapine Microspheres. International Journal of Biomaterials No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-469648
American Medical Association (AMA)
D'Souza, Susan& Faraj, Jabar A.& Giovagnoli, Stefano& DeLuca, Patrick P.. IVIVC from Long Acting Olanzapine Microspheres. International Journal of Biomaterials. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-469648
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469648