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Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra
Joint Authors
Rampersaud, N.
Harkavyi, A.
Whitton, P. S.
Source
Journal of Neurodegenerative Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Glucagon-like peptide-1 receptor (GLP-1R) activation by exendin-4 (EX-4) is effective in preclinical models of Parkinson’s disease (PD) and appears to promote neurogenesis even in severely lesioned rats.
In the present study, we determined the effects of EX-4 on cellular BrdU incorporation in the rat subventricular zone (SVZ) and substantia nigra (SN).
We also determined the specificity of this effect with the GLP-1R antagonist EX-(9-39) as well as the potential role of dopamine (DA) D3 receptors.
Rats were administered 6-OHDA and 1 week later given EX-4 alone, with EX-(9-39) or nafadotride (D3 antagonist) and BrdU.
Seven days later, rats were challenged with apomorphine to evaluate circling.
Extracellular DA was measured using striatal microdialysis and subsequently tissue DA measured.
Tyrosine hydroxylase and BrdU were verified using immunohistochemistry.
Apomorphine circling was reversed by EX-4 in lesioned rats, an effect reduced by EX-4, while both EX-(9-39) and NAF attenuated this.
6-OHDA decreased extracellular and tissue DA, both reversed by EX-4 but again attenuated by EX-(9-39) or NAF.
Analysis of BrdU+ cells in the SVZ revealed increases in 6-OHDA-treated rats which were reversed by EX-4 and antagonised by either EX-(9-39) or NAF, while in the SN the opposite profile was seen.
American Psychological Association (APA)
Harkavyi, A.& Rampersaud, N.& Whitton, P. S.. 2013. Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra. Journal of Neurodegenerative Diseases،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-469655
Modern Language Association (MLA)
Harkavyi, A.…[et al.]. Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra. Journal of Neurodegenerative Diseases No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-469655
American Medical Association (AMA)
Harkavyi, A.& Rampersaud, N.& Whitton, P. S.. Neuroprotection by Exendin-4 Is GLP-1 Receptor Specific but DA D3 Receptor Dependent, Causing Altered BrdU Incorporation in Subventricular Zone and Substantia Nigra. Journal of Neurodegenerative Diseases. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-469655
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469655