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Facilitating Effects of NanoparticlesMaterials on Sensitive Immune-Related Lung Disorders
Joint Authors
Takano, Hirohisa
Inoue, Ken-ichiro
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Engineering Sciences and Information Technology
Chemistry
Civil Engineering
Abstract EN
Although the adverse health effects of nanoparticles/materials have been proposed and are being clarified, their facilitating effects on preexisting pathological conditions have not been fully examined.
In this paper, we provide insights into the immunotoxicity of nanoparticles/materials as an aggravating factor in hypersusceptible subjects, especially those with immune-related respiratory disorders using our in vivo experimental model.
We first exhibit the effects of nanoparticles/materials on lung inflammation induced by bacterial endotoxin (lipopolysaccharide: LPS) in vivo as a disease model in innate immunity, and demonstrated that nanoparticles instilled through both an intratracheal tube and an inhalation system can exacerbate the lung inflammation.
Secondly, we introduce the effects of nanoparticles/materials on allergic asthma in vivo as a disease model in adaptive immunity, and showed that repetitive pulmonary exposure to nanoparticles has aggravating effects on allergic airway inflammation, including adjuvant effects on Th2-milieu.
Taken together, nanoparticle exposure may synergistically facilitate pathological inflammatory conditions in the lung via both innate and adaptive immunological abnormalities.
American Psychological Association (APA)
Inoue, Ken-ichiro& Takano, Hirohisa. 2010. Facilitating Effects of NanoparticlesMaterials on Sensitive Immune-Related Lung Disorders. Journal of Nanomaterials،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469680
Modern Language Association (MLA)
Inoue, Ken-ichiro& Takano, Hirohisa. Facilitating Effects of NanoparticlesMaterials on Sensitive Immune-Related Lung Disorders. Journal of Nanomaterials No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-469680
American Medical Association (AMA)
Inoue, Ken-ichiro& Takano, Hirohisa. Facilitating Effects of NanoparticlesMaterials on Sensitive Immune-Related Lung Disorders. Journal of Nanomaterials. 2010. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-469680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469680