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The Importance of Mitochondrial DNA in Aging and Cancer
Joint Authors
Singh, Keshav K.
Marcker, Maiken Lise
Desler, Claus
Rasmussen, Lene Juel
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Mitochondrial dysfunction has been implicated in premature aging, age-related diseases, and tumor initiation and progression.
Alterations of the mitochondrial genome accumulate both in aging tissue and tumors.
This paper describes our contemporary view of mechanisms by which alterations of the mitochondrial genome contributes to the development of age- and tumor-related pathological conditions.
The mechanisms described encompass altered production of mitochondrial ROS, altered regulation of the nuclear epigenome, affected initiation of apoptosis, and a limiting effect on the production of ribonucleotides and deoxyribonucleotides.
American Psychological Association (APA)
Desler, Claus& Marcker, Maiken Lise& Singh, Keshav K.& Rasmussen, Lene Juel. 2011. The Importance of Mitochondrial DNA in Aging and Cancer. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469695
Modern Language Association (MLA)
Desler, Claus…[et al.]. The Importance of Mitochondrial DNA in Aging and Cancer. Journal of Aging Research No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-469695
American Medical Association (AMA)
Desler, Claus& Marcker, Maiken Lise& Singh, Keshav K.& Rasmussen, Lene Juel. The Importance of Mitochondrial DNA in Aging and Cancer. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469695
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469695