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Increasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C
Joint Authors
Chun, Yoon Sun
Park, Myoung Kyu
Oh, Hyun Geun
Chung, Sungkwon
Kim, Tae-Wan
Source
Journal of Neurodegenerative Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-07
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Cerebral elevation of 42-residue amyloid β-peptide (Aβ42) triggers neuronal dysfunction in Alzheimer's disease (AD).
Even though a number of cholesterol modulating agents have been shown to affect Aβ generation, the role of cholesterol in the pathogenesis of AD is not clear yet.
Recently, we have shown that increased membrane cholesterol levels downregulates phosphatidylinositol 4,5-bisphosphate (PIP2) via activation of phospholipase C (PLC).
In this study, we tested whether membrane cholesterol levels may affect the Aβ42 production via changing PIP2 levels.
Increasing membrane cholesterol levels decreased PIP2 and increased secreted Aβ42.
Supplying PIP2, by using a PIP2-carrier system, blocked the effect of cholesterol on Aβ42.
We also found that cholesterol increased the expressions of β1 and β3 PLC isoforms (PLCβ1, PLCβ3).
Silencing the expression of PLCβ1 prevented the effects of cholesterol on PIP2 levels as well as on Aβ42 production, suggesting that increased membrane cholesterol levels increased secreted Aβ42 by downregulating PIP2 via enhancing the expression of PLCβ1.
Thus, cholesterol metabolism may be linked to Aβ42 levels via PLCβ1 expression and subsequent changes in PIP2 metabolism.
American Psychological Association (APA)
Chun, Yoon Sun& Oh, Hyun Geun& Park, Myoung Kyu& Kim, Tae-Wan& Chung, Sungkwon. 2013. Increasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C. Journal of Neurodegenerative Diseases،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-469731
Modern Language Association (MLA)
Chun, Yoon Sun…[et al.]. Increasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C. Journal of Neurodegenerative Diseases No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-469731
American Medical Association (AMA)
Chun, Yoon Sun& Oh, Hyun Geun& Park, Myoung Kyu& Kim, Tae-Wan& Chung, Sungkwon. Increasing Membrane Cholesterol Level Increases the Amyloidogenic Peptide by Enhancing the Expression of Phospholipase C. Journal of Neurodegenerative Diseases. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-469731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469731