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Hyaluronan Produced by Smooth Muscle Cells Plays a Critical Role in Neointima Formation
Joint Authors
Deleonibus, Sara
Passi, Alberto
Karousou, Evgenia
Viola, Manuela
Vigetti, Davide
De Luca, Giancarlo
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Large body of evidence supports the idea that microenvironment plays a critical role in several pathologies including atherosclerosis and cancer.
The amount of hyaluronan (HA) is involved in the microenvironment alterations and the concentration of this polymer reflects the progression of the diseases promoting neoangiogenesis, cell migration, and inflammation.
The HA synthesis is regulated by several factors: UDP sugar precursors availability and the phosphorylation of synthetic enzyme HAS2 as well as specific drugs reducing the UDP precursors.
The HAS2 phosphorylation is done by AMP kinase, a sensor of cell energy.
When the cells have low energy, AMP kinase is activated and modifies covalently the regulatory enzymes, blocking all biosynthetic processes and activating the energy producing metabolism.
It was recently reported that the hexosamine biosynthetic pathway (HBP) may increase the concentration of HA precursor UDP-N-acetylglucosamine (UDP-GlcNAc) leading to an increase of HA synthesis.
We demonstrated that the increase of HA synthesis depends on the HAS2 post translational modification O-GlcNAcylation, which increases HA secretion modifying a residue different from the phosphorylation site of AMP kinase.
In this report we highlighted the critical aspects of the post translational HAS2 regulation and its influence on HA synthesis.
American Psychological Association (APA)
Vigetti, Davide& Deleonibus, Sara& Karousou, Evgenia& Viola, Manuela& De Luca, Giancarlo& Passi, Alberto. 2014. Hyaluronan Produced by Smooth Muscle Cells Plays a Critical Role in Neointima Formation. Conference Papers in Science،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-469792
Modern Language Association (MLA)
Vigetti, Davide…[et al.]. Hyaluronan Produced by Smooth Muscle Cells Plays a Critical Role in Neointima Formation. Conference Papers in Science No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-469792
American Medical Association (AMA)
Vigetti, Davide& Deleonibus, Sara& Karousou, Evgenia& Viola, Manuela& De Luca, Giancarlo& Passi, Alberto. Hyaluronan Produced by Smooth Muscle Cells Plays a Critical Role in Neointima Formation. Conference Papers in Science. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-469792
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469792