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Expression of Neuroendocrine Markers in Different Molecular Subtypes of Breast Carcinoma
Joint Authors
Hartmann, Arndt
Bayer, Christian M.
Hein, Alexander
Agaimy, Abbas
Beckmann, Matthias W.
Fasching, Peter A.
Wachter, David L.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Carcinomas of the breast with neuroendocrine features are incorporated in the World Health Organization classification since 2003 and include well-differentiated neuroendocrine tumors, poorly differentiated neuroendocrine carcinomas/small cell carcinomas, and invasive breast carcinomas with neuroendocrine differentiation.
Neuroendocrine differentiation is known to be more common in certain low-grade histologic special types and has been shown to mainly cluster to the molecular (intrinsic) luminal A subtype.
Methods.
We analyzed the frequency of neuroendocrine differentiation in different molecular subtypes of breast carcinomas of no histologic special type using immunohistochemical stains with specific neuroendocrine markers (chromogranin A and synaptophysin).
Results.
We found neuroendocrine differentiation in 20% of luminal B-like carcinomas using current WHO criteria (at least 50% of tumor cells positive for synaptophysin or chromogranin A).
In contrast, no neuroendocrine differentiation was seen in luminal A-like, HER2 amplified and triple-negative carcinomas.
Breast carcinomas with neuroendocrine differentiation presented with advanced stage disease and showed aggressive behavior.
Conclusions.
We conclude that neuroendocrine differentiation is more common than assumed in poorly differentiated luminal B-like carcinomas.
Use of specific neuroendocrine markers is thus encouraged in this subtype to enhance detection of neuroendocrine differentiation and hence characterize the biological and therapeutic relevance of this finding in future studies.
American Psychological Association (APA)
Wachter, David L.& Hartmann, Arndt& Beckmann, Matthias W.& Fasching, Peter A.& Hein, Alexander& Bayer, Christian M.…[et al.]. 2014. Expression of Neuroendocrine Markers in Different Molecular Subtypes of Breast Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469795
Modern Language Association (MLA)
Wachter, David L.…[et al.]. Expression of Neuroendocrine Markers in Different Molecular Subtypes of Breast Carcinoma. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-469795
American Medical Association (AMA)
Wachter, David L.& Hartmann, Arndt& Beckmann, Matthias W.& Fasching, Peter A.& Hein, Alexander& Bayer, Christian M.…[et al.]. Expression of Neuroendocrine Markers in Different Molecular Subtypes of Breast Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469795