Redox Regulation in Amyotrophic Lateral Sclerosis
Joint Authors
Halloran, Mark A.
Atkin, Julie D.
Soo, Kai Y.
Spencer, Damian M.
Parakh, Sonam
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-25
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that results from the death of upper and lower motor neurons.
Due to a lack of effective treatment, it is imperative to understand the underlying mechanisms and processes involved in disease progression.
Regulations in cellular reduction/oxidation (redox) processes are being increasingly implicated in disease.
Here we discuss the possible involvement of redox dysregulation in the pathophysiology of ALS, either as a cause of cellular abnormalities or a consequence.
We focus on its possible role in oxidative stress, protein misfolding, glutamate excitotoxicity, lipid peroxidation and cholesterol esterification, mitochondrial dysfunction, impaired axonal transport and neurofilament aggregation, autophagic stress, and endoplasmic reticulum (ER) stress.
We also speculate that an ER chaperone protein disulphide isomerase (PDI) could play a key role in this dysregulation.
PDI is essential for normal protein folding by oxidation and reduction of disulphide bonds, and hence any disruption to this process may have consequences for motor neurons.
Addressing the mechanism underlying redox regulation and dysregulation may therefore help to unravel the molecular mechanism involved in ALS.
American Psychological Association (APA)
Parakh, Sonam& Spencer, Damian M.& Halloran, Mark A.& Soo, Kai Y.& Atkin, Julie D.. 2013. Redox Regulation in Amyotrophic Lateral Sclerosis. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-469817
Modern Language Association (MLA)
Parakh, Sonam…[et al.]. Redox Regulation in Amyotrophic Lateral Sclerosis. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-469817
American Medical Association (AMA)
Parakh, Sonam& Spencer, Damian M.& Halloran, Mark A.& Soo, Kai Y.& Atkin, Julie D.. Redox Regulation in Amyotrophic Lateral Sclerosis. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-469817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469817