Identifying Functional Mechanisms of Gene and Protein Regulatory Networks in Response to a Broader Range of Environmental Stresses
Joint Authors
Source
Comparative and Functional Genomics
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-04-28
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Cellular responses to sudden environmental stresses or physiological changes provide living organisms with the opportunity for final survival and further development.
Therefore, it is an important topic to understand protective mechanisms against environmental stresses from the viewpoint of gene and protein networks.
We propose two coupled nonlinear stochastic dynamic models to reconstruct stress-activated gene and protein regulatory networks via microarray data in response to environmental stresses.
According to the reconstructed gene/protein networks, some possible mutual interactions, feedforward and feedback loops are found for accelerating response and filtering noises in these signaling pathways.
A bow-tie core network is also identified to coordinate mutual interactions and feedforward loops, feedback inhibitions, feedback activations, and cross talks to cope efficiently with a broader range of environmental stresses with limited proteins and pathways.
American Psychological Association (APA)
Li, Cheng-Wei& Chen, Bor-Sen. 2010. Identifying Functional Mechanisms of Gene and Protein Regulatory Networks in Response to a Broader Range of Environmental Stresses. Comparative and Functional Genomics،Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-469824
Modern Language Association (MLA)
Li, Cheng-Wei& Chen, Bor-Sen. Identifying Functional Mechanisms of Gene and Protein Regulatory Networks in Response to a Broader Range of Environmental Stresses. Comparative and Functional Genomics No. 2010 (2010), pp.1-20.
https://search.emarefa.net/detail/BIM-469824
American Medical Association (AMA)
Li, Cheng-Wei& Chen, Bor-Sen. Identifying Functional Mechanisms of Gene and Protein Regulatory Networks in Response to a Broader Range of Environmental Stresses. Comparative and Functional Genomics. 2010. Vol. 2010, no. 2010, pp.1-20.
https://search.emarefa.net/detail/BIM-469824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469824