Vitamin D Receptor Polymorphisms Predispose to Primary Biliary Cirrhosis and Severity of the Disease in Polish Population
Joint Authors
Milkiewicz, Małgorzata
Loniewska, Beata
Jarowicz, Tomasz
Kempinska-Podhorodecka, Agnieszka
Wunsch, Ewa
Kaczmarczyk, Mariusz
Milkiewicz, Piotr
Raszeja-Wyszomirska, Joanna
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Primary biliary cirrhosis (PBC) is a chronic cholestatic liver condition characterized by the immune-mediated damage of the intrahepatic bile ducts.
Polymorphisms of vitamin D receptor (VDR) are considered to contribute to its pathogenesis however their incidence varies in different populations and their potential association with the course of the disease has not been studied.
In this paper we investigated the incidence and correlation of three VDR polymorphisms (BsmI, ApaI or TaqI) with various clinical, biochemical, and serological factors in a homogenous group of 143 Caucasian patients with PBC.
Control group comprises 306 DNA samples from umbilical cord blood of healthy newborn children.
When compared to controls, we observed a significant dominance of the b allele in the BsmI (OR = 1.69 [1.27–2.24]; P=0.0003) and t allele in the TaqI (OR = 0.62 [0.47–0.82], P=0.0001) in patients with PBC.
Moreover the BsmI and TaqI polymorphisms were associated with the presence of advanced fibrosis/liver cirrhosis at the diagnosis of PBC.
Pairwise linkage disequilibrium (LD) calculations proved that the analyzed SNPs are within an LD block (100% of LDs were D’>0.9).
Our study showed, for the first time, that the analyzed polymorphisms of VRD may exert an effect on a natural history of PBC.
American Psychological Association (APA)
Kempinska-Podhorodecka, Agnieszka& Wunsch, Ewa& Jarowicz, Tomasz& Raszeja-Wyszomirska, Joanna& Loniewska, Beata& Kaczmarczyk, Mariusz…[et al.]. 2012. Vitamin D Receptor Polymorphisms Predispose to Primary Biliary Cirrhosis and Severity of the Disease in Polish Population. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-469826
Modern Language Association (MLA)
Kempinska-Podhorodecka, Agnieszka…[et al.]. Vitamin D Receptor Polymorphisms Predispose to Primary Biliary Cirrhosis and Severity of the Disease in Polish Population. Gastroenterology Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-469826
American Medical Association (AMA)
Kempinska-Podhorodecka, Agnieszka& Wunsch, Ewa& Jarowicz, Tomasz& Raszeja-Wyszomirska, Joanna& Loniewska, Beata& Kaczmarczyk, Mariusz…[et al.]. Vitamin D Receptor Polymorphisms Predispose to Primary Biliary Cirrhosis and Severity of the Disease in Polish Population. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-469826
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469826