Schwann Cells Overexpressing FGF-2 Alone or Combined with Manual Stimulation Do Not Promote Functional Recovery after Facial Nerve Injury
Joint Authors
Dunlop, Sarah A.
Haastert-Talini, Kirsten
Angelov, Doychin N.
Grothe, Claudia
Grosheva, Maria
Skouras, Emmanouil
Michael, Joern
Guntinas-Lichius, Orlando
Angelova, Srebrina K.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To determine whether transplantation of Schwann cells (SCs) overexpressing different isoforms of fibroblast growth factor 2 (FGF-2) combined with manual stimulation (MS) of vibrissal muscles improves recovery after facial nerve transection in adult rat.
Procedures.
Transected facial nerves were entubulated with collagen alone or collagen plus naïve SCs or transfected SCs.
Half of the rats received daily MS.
Collateral branching was quantified from motoneuron counts after retrograde labeling from 3 facial nerve branches.
Quality assessment of endplate reinnervation was combined with video-based vibrissal function analysis.
Results.
There was no difference in the extent of collateral axonal branching.
The proportion of polyinnervated motor endplates for either naïve SCs or FGF-2 over-expressing SCs was identical.
Postoperative MS also failed to improve recovery.
Conclusions.
Neither FGF-2 isoform changed the extent of collateral branching or polyinnervation of motor endplates; furthermore, this motoneuron response could not be overridden by MS.
American Psychological Association (APA)
Haastert-Talini, Kirsten& Grosheva, Maria& Angelova, Srebrina K.& Guntinas-Lichius, Orlando& Skouras, Emmanouil& Michael, Joern…[et al.]. 2009. Schwann Cells Overexpressing FGF-2 Alone or Combined with Manual Stimulation Do Not Promote Functional Recovery after Facial Nerve Injury. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-469831
Modern Language Association (MLA)
Haastert-Talini, Kirsten…[et al.]. Schwann Cells Overexpressing FGF-2 Alone or Combined with Manual Stimulation Do Not Promote Functional Recovery after Facial Nerve Injury. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-469831
American Medical Association (AMA)
Haastert-Talini, Kirsten& Grosheva, Maria& Angelova, Srebrina K.& Guntinas-Lichius, Orlando& Skouras, Emmanouil& Michael, Joern…[et al.]. Schwann Cells Overexpressing FGF-2 Alone or Combined with Manual Stimulation Do Not Promote Functional Recovery after Facial Nerve Injury. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-469831
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469831