Effect of Prenatal Polycyclic Aromatic Hydrocarbons Exposure on Birth Outcomes : The Polish Mother and Child Cohort Study
Joint Authors
Hanke, Wojciech
Sobala, Wojciech
Polanska, Kinga
Magnus, Per
Jurewicz, Joanna
Seidel, Albrecht
Dettbarn, Gerhard
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study was to assess the impact of PAH exposure on various anthropometric measures of birth outcomes.
The study population consisted of 210 nonsmoking pregnant women.
Urine samples collected between 20th and 24th week of pregnancy were used for analysis of the following PAH metabolites: 1-, 2-, 3-, 4-, and 9-hydroxyphenanthrene (1-, 2-, 3-, 4-, and 9-OH-PHE), 1-hydroxypyrene (1-OH-PYR), 1,6 + 1,8-dihydroxypyrene (DI-OH-PYR), phenanthrene trans-1,2-dihydrodiol (PHE-1,2-diol), and phenanthrene trans-9,10-dihydrodiol (PHE-9,10-diol) by gas chromatography-mass spectrometry.
Environmental tobacco smoke exposure (ETS) was assessed by cotinine level in saliva using a stable isotope dilution LC-ESI-MS/MS method.
The mean PAH metabolite concentrations were in the range of 0.15 µg/g creatinine for 9-OH-PHE to 5.9 µg/g creatinine for PHE-9,10-diol.
It was shown that none of the individual PAH exposure markers demonstrate a statistically significant influence on birth outcomes.
Interestingly a statistically significant association was found between the sum of OH-PHE along with cotinine level and the cephalization index after adjusting for potential confounders (P=0.04).
This study provides evidence that combined exposure of pregnant women to common environmental pollutants such as PAH and ETS might adversely affect fetal development.
Thus, reduction of human exposure to these mixtures of hazardous compounds would in particular result in substantial health benefits for newborns.
American Psychological Association (APA)
Polanska, Kinga& Dettbarn, Gerhard& Jurewicz, Joanna& Sobala, Wojciech& Magnus, Per& Seidel, Albrecht…[et al.]. 2014. Effect of Prenatal Polycyclic Aromatic Hydrocarbons Exposure on Birth Outcomes : The Polish Mother and Child Cohort Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-469833
Modern Language Association (MLA)
Polanska, Kinga…[et al.]. Effect of Prenatal Polycyclic Aromatic Hydrocarbons Exposure on Birth Outcomes : The Polish Mother and Child Cohort Study. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-469833
American Medical Association (AMA)
Polanska, Kinga& Dettbarn, Gerhard& Jurewicz, Joanna& Sobala, Wojciech& Magnus, Per& Seidel, Albrecht…[et al.]. Effect of Prenatal Polycyclic Aromatic Hydrocarbons Exposure on Birth Outcomes : The Polish Mother and Child Cohort Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-469833
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469833