A New Case of DRESS Syndrome Induced by Sulfasalazine and Triggered by Amoxicillin

Joint Authors

Girelli, Francesco
Bernardi, Simone
Parente, Gianluca
Serra, Luigi
Gardelli, Lucia
Dubini, Alessandra
Nizzoli, Maurizio
Bassi, Bruna

Source

Case Reports in Rheumatology

Issue

Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2013-07-10

Country of Publication

Egypt

No. of Pages

3

Main Subjects

Diseases

Abstract EN

Drug Rash Eosinophilia Systemic Symptoms (DRESS) syndrome is a systemic hypersensitivity reaction characterized by exfoliative dermatitis and maculopapular rash, lymphadenopathy, fever, eosinophilia, leukocytosis, and involvement of internal organs as liver, lung, heart, and kidney; the disorder starts within 2–6 weeks after taking a drug with an incidence that ranges from 1/1000 to 1/10000 exposures.

Fatal cases are reported.

The exact pathogenesis of DRESS syndrome is not completely understood, while it is reported that amoxicillin could trigger it in patients who are taking allopurinol, sulfasalazine, NSAIDs, carbamazepine, strontium ranelate, lisinopril, lansoprazole, and minocycline.

Amoxicillin could act directly, inducing the reactivation of a viral infection (HHV 6 and EBV) with symptoms similar to DRESS syndrome or by reducing the patients’ ability to detoxify the body from substances chronically taken.

We describe a case of a patient admitted to our hospital for a DRESS syndrome flared after amoxicilline intake during treatment with sulfasalazine; this combination can activate severe reactions often with an insidious onset that can mimic an infectious disease.

American Psychological Association (APA)

Girelli, Francesco& Bernardi, Simone& Gardelli, Lucia& Bassi, Bruna& Parente, Gianluca& Dubini, Alessandra…[et al.]. 2013. A New Case of DRESS Syndrome Induced by Sulfasalazine and Triggered by Amoxicillin. Case Reports in Rheumatology،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-469850

Modern Language Association (MLA)

Girelli, Francesco…[et al.]. A New Case of DRESS Syndrome Induced by Sulfasalazine and Triggered by Amoxicillin. Case Reports in Rheumatology No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-469850

American Medical Association (AMA)

Girelli, Francesco& Bernardi, Simone& Gardelli, Lucia& Bassi, Bruna& Parente, Gianluca& Dubini, Alessandra…[et al.]. A New Case of DRESS Syndrome Induced by Sulfasalazine and Triggered by Amoxicillin. Case Reports in Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-469850

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-469850