Widespread Disulfide Bonding in Proteins from Thermophilic Archaea
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-20
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Disulfide bonds are generally not used to stabilize proteins in the cytosolic compartments of bacteria or eukaryotic cells, owing to the chemically reducing nature of those environments.
In contrast, certain thermophilic archaea use disulfide bonding as a major mechanism for protein stabilization.
Here, we provide a current survey of completely sequenced genomes, applying computational methods to estimate the use of disulfide bonding across the Archaea.
Microbes belonging to the Crenarchaeal branch, which are essentially all hyperthermophilic, are universally rich in disulfide bonding while lesser degrees of disulfide bonding are found among the thermophilic Euryarchaea, excluding those that are methanogenic.
The results help clarify which parts of the archaeal lineage are likely to yield more examples and additional specific data on protein disulfide bonding, as increasing genomic sequencing efforts are brought to bear.
American Psychological Association (APA)
Jorda, Julien& Yeates, Todd O.. 2011. Widespread Disulfide Bonding in Proteins from Thermophilic Archaea. Archaea،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469851
Modern Language Association (MLA)
Jorda, Julien& Yeates, Todd O.. Widespread Disulfide Bonding in Proteins from Thermophilic Archaea. Archaea No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-469851
American Medical Association (AMA)
Jorda, Julien& Yeates, Todd O.. Widespread Disulfide Bonding in Proteins from Thermophilic Archaea. Archaea. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-469851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469851