The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma
Joint Authors
Jiang, Chunping
Wu, Junhua
Wang, Zhongxia
Luo, Dongjun
Wu, Junyi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma (HCC).
Hypoxia can promote tumor progression and induce radiation and chemotherapy resistance.
As one of the major mediators of hypoxic response, hypoxia inducible factor-1 (HIF-1) has been shown to activate hypoxia-responsive genes, which are involved in multiple aspects of tumorigenesis and cancer progression, including proliferation, metabolism, angiogenesis, invasion, metastasis and therapy resistance.
It has been demonstrated that a high level of HIF-1 in the HCC microenvironment leads to enhanced proliferation and survival of HCC cells.
Accordingly, overexpression, of HIF-1 is associated with poor prognosis in HCC.
In this review, we described the mechanism by which HIF-1 is regulated and how HIF-1 mediates the biological effects of hypoxia in tissues.
We also summarized the latest findings concerning the role of HIF-1 in the development of HCC, which could shed light on new therapeutic approaches for the treatment of HCC.
American Psychological Association (APA)
Luo, Dongjun& Wang, Zhongxia& Wu, Junyi& Jiang, Chunping& Wu, Junhua. 2014. The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-469862
Modern Language Association (MLA)
Luo, Dongjun…[et al.]. The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-469862
American Medical Association (AMA)
Luo, Dongjun& Wang, Zhongxia& Wu, Junyi& Jiang, Chunping& Wu, Junhua. The Role of Hypoxia Inducible Factor-1 in Hepatocellular Carcinoma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-469862
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469862