Chromatin from Peripheral Blood Mononuclear Cells as Biomarkers for Epigenetic Abnormalities in Schizophrenia
Joint Authors
Sharma, Rajiv P.
Gavin, David P.
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-22
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Background.
Studies have implicated abnormalities in epigenetic gene regulation in schizophrenia.
Presentation.
We hypothesize that identifying abnormalities in chromatin structure and the epigenetic machinery in peripheral blood mononuclear cells (PBMC) from schizophrenia patients could (a) help characterize a subset of schizophrenia patients and (b) lead to targeted pharmacological interventions.
Testing.
Investigate the relationship between clinical symptoms, demographics, hormonal fluctuations, substance abuse, disease characteristics across the major mental illnesses, and epigenetic parameters in PBMC.
In addition, examine the effects of individual antipsychotics, mood stabilizers, as well as experimental agents both as clinically prescribed as well as in cultured PBMC to understand the effects of these agents on chromatin.
Implications.
If PBMC could serve as a reliable model of overall epigenetic mechanisms then this could lead to a “biomarker” approach to revealing pathological chromatin state in schizophrenia.
This approach may provide an informed method for selecting chromatin modifying agents for psychiatric disorders.
American Psychological Association (APA)
Gavin, David P.& Sharma, Rajiv P.. 2009. Chromatin from Peripheral Blood Mononuclear Cells as Biomarkers for Epigenetic Abnormalities in Schizophrenia. Cardiovascular Psychiatry and Neurology،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-469897
Modern Language Association (MLA)
Gavin, David P.& Sharma, Rajiv P.. Chromatin from Peripheral Blood Mononuclear Cells as Biomarkers for Epigenetic Abnormalities in Schizophrenia. Cardiovascular Psychiatry and Neurology No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-469897
American Medical Association (AMA)
Gavin, David P.& Sharma, Rajiv P.. Chromatin from Peripheral Blood Mononuclear Cells as Biomarkers for Epigenetic Abnormalities in Schizophrenia. Cardiovascular Psychiatry and Neurology. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-469897
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469897