Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice
Joint Authors
Hu, Zhenzhen
Wu, Lei
Zhang, Dalei
Yang, Shulong
Zhou, Ling
Wang, Jinglei
Kuang, Haibin
Wei, Jie
Zou, Weiying
Yang, Bei
Liu, Fangming
Zou, Ting
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-02
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Perfluorooctanoic acid (PFOA) is widely present in the environment and has been reported to induce hepatic toxicity in animals and humans.
In this study, mice were orally administered different concentrations of PFOA (2.5, 5, or 10 mg/kg/day).
Histological examination showed that the exposure to PFOA for 14 consecutive days led to serious hepatocellular injury and obvious inflammatory cell infiltration.
In addition, malondialdehyde formation and hydrogen peroxide generation, indicators of oxidative stress, were significantly induced by PFOA treatment in the liver of mice.
Furthermore, hepatic levels of interleukin-6, cyclooxygenase-2, and C-reactive protein, markers of inflammatory response, were markedly increased by exposure to PFOA in mice.
These results demonstrated that PFOA-induced hepatic toxicity may be involved in oxidative stress and inflammatory response in mice.
American Psychological Association (APA)
Yang, Bei& Zou, Weiying& Hu, Zhenzhen& Liu, Fangming& Zhou, Ling& Yang, Shulong…[et al.]. 2014. Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-469920
Modern Language Association (MLA)
Yang, Bei…[et al.]. Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-469920
American Medical Association (AMA)
Yang, Bei& Zou, Weiying& Hu, Zhenzhen& Liu, Fangming& Zhou, Ling& Yang, Shulong…[et al.]. Involvement of Oxidative Stress and Inflammation in Liver Injury Caused by Perfluorooctanoic Acid Exposure in Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-469920
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469920