Antioxidants, Phytochemicals, and Cytotoxicity Studies on Phaleria macrocarpa (Scheff.) Boerl Seeds
Joint Authors
Abd Malek, Sri Nurestri
Karsani, Saiful Anuar
Lay, Ma Ma
Banisalam, Behrooz
Mohajer, Sadegh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
In recent years, the utilization of certain medicinal plants as therapeutic agents has drastically increased.
Phaleria macrocarpa (Scheff.) Boerl is frequently used in traditional medicine.
The present investigation was undertaken with the purpose of developing pharmacopoeial standards for this species.
Nutritional values such as ash, fiber, protein, fat, and carbohydrate contents were investigated, and phytochemical screenings with different reagents showed the presence of flavonoids, glycosides, saponin glycosides, phenolic compounds, steroids, tannins, and terpenoids.
Our results also revealed that the water fraction had the highest antioxidant activity compared to the methanol extract and other fractions.
The methanol and the fractionated extracts (hexane, chloroform, ethyl acetate, and water) of P.
macrocarpa seeds were also investigated for their cytotoxic effects on selected human cancer cells lines (MCF-7, HT-29, MDA-MB231, Ca Ski, and SKOV-3) and a normal human fibroblast lung cell line (MRC-5).
Information from this study can be applied for future pharmacological and therapeutic evaluations of the species, and may assist in the standardization for quality, purity, and sample identification.
To the best of our knowledge, this is the first report on the phytochemical screening and cytotoxic effect of the crude and fractionated extracts of P.
macrocarpa seeds on selected cells lines.
American Psychological Association (APA)
Lay, Ma Ma& Karsani, Saiful Anuar& Banisalam, Behrooz& Mohajer, Sadegh& Abd Malek, Sri Nurestri. 2014. Antioxidants, Phytochemicals, and Cytotoxicity Studies on Phaleria macrocarpa (Scheff.) Boerl Seeds. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-469933
Modern Language Association (MLA)
Lay, Ma Ma…[et al.]. Antioxidants, Phytochemicals, and Cytotoxicity Studies on Phaleria macrocarpa (Scheff.) Boerl Seeds. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-469933
American Medical Association (AMA)
Lay, Ma Ma& Karsani, Saiful Anuar& Banisalam, Behrooz& Mohajer, Sadegh& Abd Malek, Sri Nurestri. Antioxidants, Phytochemicals, and Cytotoxicity Studies on Phaleria macrocarpa (Scheff.) Boerl Seeds. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-469933
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469933