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Superficial Dsg2 Expression Limits Epidermal Blister Formation Mediated by Pemphigus Foliaceus Antibodies and Exfoliative Toxins
Joint Authors
Mahoney, My G.
Dowling, Alicia
Medhat, Walid
Hu, Ying
Brennan, Donna
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cell-cell adhesion mediated by desmosomes is crucial for maintaining proper epidermal structure and function, as evidenced by several severe and potentially fatal skin disorders involving impairment of desmosomal proteins.
Pemphigus foliaceus (PF) and staphylococcal scalded skin syndrome (SSSS) are subcorneal blistering diseases resulting from loss of function of the desmosomal cadherin, desmoglein 1 (Dsg1).
To further study the pathomechanism of these diseases and to assess the adhesive properties of Dsg2, we employed a recently established transgenic (Tg) mouse model expressing Dsg2 in the superficial epidermis.
Neonatal Tg and wild type (WT) mice were injected with purified ETA or PF Ig.
We showed that ectopic expression of Dsg2 reduced the extent of blister formation in response to both ETA and PF Ig.
In response to PF Ig, we observed either a dramatic loss or a reorganization of Dsg1-α, Dsg1-β, and, to a lesser extent, Dsg1-γ, in WT mice.
The Inv-Dsg2 Tg mice showed enhanced retention of Dsg1 at the cell-cell border.
Collectively, our data support the role for Dsg2 in cell adhesion and suggest that ectopic superficial expression of Dsg2 can increase membrane preservation of Dsg1 and limit epidermal blister formation mediated by PF antibodies and exfoliative toxins.
American Psychological Association (APA)
Brennan, Donna& Hu, Ying& Medhat, Walid& Dowling, Alicia& Mahoney, My G.. 2010. Superficial Dsg2 Expression Limits Epidermal Blister Formation Mediated by Pemphigus Foliaceus Antibodies and Exfoliative Toxins. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-469940
Modern Language Association (MLA)
Brennan, Donna…[et al.]. Superficial Dsg2 Expression Limits Epidermal Blister Formation Mediated by Pemphigus Foliaceus Antibodies and Exfoliative Toxins. Dermatology Research and Practice No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-469940
American Medical Association (AMA)
Brennan, Donna& Hu, Ying& Medhat, Walid& Dowling, Alicia& Mahoney, My G.. Superficial Dsg2 Expression Limits Epidermal Blister Formation Mediated by Pemphigus Foliaceus Antibodies and Exfoliative Toxins. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-469940
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469940