Myeloid Sarcoma : The Clinician's Point of View
Joint Authors
Visani, G.
Mario, Tiribelli
Russo, D.
Candoni, A.
Malagola, Michele
Isidori, Alessandro
Source
Leukemia Research and Treatment
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-2, 2 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-27
Country of Publication
Egypt
No. of Pages
2
Main Subjects
Mechanical Engineering
Medicine
Abstract EN
Myeloid Sarcoma may occur in patients with an acute or chronic myeloproliferative disorder as well as de novo, with no apparent sign or symptom of concomitant haematological disease.
The patients are preferentially young male and the site of disease localization may vary from central nervous system to pleura and thorax, with a common involvement of the reticuloendothelial system.
The disease often shows chromosomal rearrangements, involving chromosomes 7, 8 and 3 and sometimes a complex karyotype (more than 3 abnormalities) is detected at diagnosis.
The prognosis of this disease is dismal and only high-dose chemotherapy with autologous or allogeneic stem cells transplantation (auto or allo-SCT) may be potentially curative.
In the absence of definitive elements that can define the prognosis of extra-medullary localization of “standard risk” AML, Clinicians should pursue the collection of data from different Centres and design of homogeneous treatment strategies, that could integrate standard chemotherapy with specific approaches, such as radiotherapy, transplant procedures or, in selected cases (such as those displaying molecular abnormalities involving protein tyrosine-kinases), molecularly targeted therapies.
American Psychological Association (APA)
Malagola, Michele& Mario, Tiribelli& Russo, D.& Candoni, A.& Visani, G.& Isidori, Alessandro. 2011. Myeloid Sarcoma : The Clinician's Point of View. Leukemia Research and Treatment،Vol. 2011, no. 2011, pp.1-2.
https://search.emarefa.net/detail/BIM-469944
Modern Language Association (MLA)
Malagola, Michele…[et al.]. Myeloid Sarcoma : The Clinician's Point of View. Leukemia Research and Treatment No. 2011 (2011), pp.1-2.
https://search.emarefa.net/detail/BIM-469944
American Medical Association (AMA)
Malagola, Michele& Mario, Tiribelli& Russo, D.& Candoni, A.& Visani, G.& Isidori, Alessandro. Myeloid Sarcoma : The Clinician's Point of View. Leukemia Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-2.
https://search.emarefa.net/detail/BIM-469944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469944