Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism
Joint Authors
Kertscho, Harry
Habler, Oliver
Meier, Jens
Lauscher, Patrick
Lauscher, Sabine
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Aim.
Ventilation with pure oxygen (hyperoxic ventilation: HV) is thought to decrease whole body oxygen consumption (VO2).
However, the validity and impact of this phenomenon remain ambiguous; until now, under hyperoxic conditions, VO2 has only been determined by the reverse Fick principle, a method with inherent methodological problems.
The goal of this study was to determine changes of VO2, carbon dioxide production (VCO2), and the respiratory quotient (RQ) during normoxic and hyperoxic ventilation, using a metabolic monitor.
Methods.
After providing signed informed consent and institutional acceptance, 14 healthy volunteers were asked to sequentially breathe room air, pure oxygen, and room air again.
VO2, VCO2, RQ, and energy expenditure (EE) were determined by indirect calorimetry using a modified metabolic monitor during HV.
Results.
HV reduced VO2 from 3.4 (3.0/4.0) mL/kg/min to 2.8 (2.5/3.6) mL/kg/min (P<0.05), whereas VCO2 remained constant (3.0 [2.6/3.6] mL/kg/min versus 3.0 [2.6/3.5] mL/kg/min, n.s.).
After onset of HV, RQ increased from 0.9 (0.8/0.9) to 1.1 (1.0/1.1).
Most changes during HV were immediately reversed during subsequent normoxic ventilation.
Conclusion.
HV not only reduces VO2, but also increases the respiratory quotient.
This might be interpreted as an indicator of the substantial metabolic changes induced by HV.
However, the impact of this phenomenon requires further study.
American Psychological Association (APA)
Lauscher, Patrick& Lauscher, Sabine& Kertscho, Harry& Habler, Oliver& Meier, Jens. 2012. Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-469947
Modern Language Association (MLA)
Lauscher, Patrick…[et al.]. Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism. The Scientific World Journal No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-469947
American Medical Association (AMA)
Lauscher, Patrick& Lauscher, Sabine& Kertscho, Harry& Habler, Oliver& Meier, Jens. Hyperoxia Reversibly Alters Oxygen Consumption and Metabolism. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-469947
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469947