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Association of Genetic Variation in Calmodulin and Left Ventricular Mass in Full-Term Newborns
Joint Authors
Gorący, Iwona
Gorący, Jarosław
Skonieczna-Żydecka, Karolina
Kaczmarczyk, Mariusz
Dawid, Grażyna
Ciechanowicz, Andrzej
Source
International Journal of Genomics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Calmodulin II (CALM2) gene polymorphism might be responsible for the variation in the left ventricular mass amongst healthy individuals.
The aim was to evaluate the correlation between left ventricular mass (LVM) and g.474955027G>A (rs7565161) polymorphism adjacent to the CALM2 gene.
Healthy Polish newborns (n = 206) were recruited.
Two-dimensional M-mode echocardiography was used to assess LVM.
Polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism and sequencing analyses.
The carriers of the G allele of the CALM2 polymorphism had significantly higher left ventricular mass/weight (LVM/BW) values, when compared with newborns homozygous for the A allele (3.1 g/m2 versus 2.5 g/m2, Padjusted = 0.036).
The AG genotype of CALM2 was associated with the highest values of LVM/BW, exhibiting a pattern of overdominance (2.9 g/kg versus 3.1 g/kg versus 2.5 g/kg, Padjusted = 0.037).
The results of this study suggest that G>A CALM2 polymorphism may account for subtle variation in LVM at birth.
American Psychological Association (APA)
Gorący, Iwona& Gorący, Jarosław& Skonieczna-Żydecka, Karolina& Kaczmarczyk, Mariusz& Dawid, Grażyna& Ciechanowicz, Andrzej. 2013. Association of Genetic Variation in Calmodulin and Left Ventricular Mass in Full-Term Newborns. International Journal of Genomics،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469957
Modern Language Association (MLA)
Gorący, Iwona…[et al.]. Association of Genetic Variation in Calmodulin and Left Ventricular Mass in Full-Term Newborns. International Journal of Genomics No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-469957
American Medical Association (AMA)
Gorący, Iwona& Gorący, Jarosław& Skonieczna-Żydecka, Karolina& Kaczmarczyk, Mariusz& Dawid, Grażyna& Ciechanowicz, Andrzej. Association of Genetic Variation in Calmodulin and Left Ventricular Mass in Full-Term Newborns. International Journal of Genomics. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-469957
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469957