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A Preliminary Study of the Influence of Age of Onset and Childhood Trauma on Cortical Thickness in Major Depressive Disorder
Joint Authors
Goodyear, Bradley
Jaworska, Natalia
Ramasubbu, Rajamannar
Cortese, Filomeno
MacMaster, Frank P.
Gaxiola, Ismael
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Major depressive disorder (MDD) neural underpinnings may differ based on onset age and childhood trauma.
We assessed cortical thickness in patients who differed in age of MDD onset and examined trauma history influence.
Methods.
Adults with MDD (N=36) and controls (HC; N=18) underwent magnetic resonance imaging.
Twenty patients had MDD onset <24 years of age (pediatric onset) and 16 had onset >25 years of age (adult onset).
The MDD group was also subdivided into those with (N=12) and without (N=19) physical and/or sexual abuse as assessed by the Childhood Trauma Questionnaire (CTQ).
Cortical thickness was analyzed with FreeSurfer software.
Results.
Thicker frontal pole and a tendency for thinner transverse temporal cortices existed in MDD.
The former was driven by the pediatric onset group and abuse history (independently), particularly in the right frontal pole.
Inverse correlations existed between CTQ scores and frontal pole cortex thickness.
A similar inverse relation existed with left inferior and right superior parietal cortex thickness.
The superior temporal cortex tended to be thinner in pediatric versus adult onset groups with childhood abuse.
Conclusions.
This preliminary work suggests neural differences between pediatric and adult MDD onset.
Trauma history also contributes to cytoarchitectural modulation.
Thickened frontal pole cortices as a compensatory mechanism in MDD warrant evaluation.
American Psychological Association (APA)
Jaworska, Natalia& MacMaster, Frank P.& Gaxiola, Ismael& Cortese, Filomeno& Goodyear, Bradley& Ramasubbu, Rajamannar. 2014. A Preliminary Study of the Influence of Age of Onset and Childhood Trauma on Cortical Thickness in Major Depressive Disorder. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469964
Modern Language Association (MLA)
Jaworska, Natalia…[et al.]. A Preliminary Study of the Influence of Age of Onset and Childhood Trauma on Cortical Thickness in Major Depressive Disorder. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-469964
American Medical Association (AMA)
Jaworska, Natalia& MacMaster, Frank P.& Gaxiola, Ismael& Cortese, Filomeno& Goodyear, Bradley& Ramasubbu, Rajamannar. A Preliminary Study of the Influence of Age of Onset and Childhood Trauma on Cortical Thickness in Major Depressive Disorder. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-469964
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469964