Demonstration of Redox Potential of Metschnikowia koreensis for Stereoinversion of Secondary Alcohols1,2-Diols
Joint Authors
Banoth, Linga
Meena, Vachan Singh
Banerjee, Uttam Chand
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The present work reports the Metschnikowia koreensis-catalyzed one-pot deracemization of secondary alcohols/1,2-diols and their derivatives with in vivo cofactor regeneration.
Reaction is stereoselective and proceeds with sequential oxidation of (R)-secondary alcohols to the corresponding ketones and the reduction of the ketones to (S)-secondary alcohols.
Method is applicable to a repertoire of racemic aryl secondary alcohols and 1,2-diols establishing a wide range of substrate specificity of M.
koreensis.
This ecofriendly method afforded the product in high yield (88%) and excellent optical purity (>98% ee), minimizing the requirement of multistep reaction and expensive cofactor.
American Psychological Association (APA)
Meena, Vachan Singh& Banoth, Linga& Banerjee, Uttam Chand. 2014. Demonstration of Redox Potential of Metschnikowia koreensis for Stereoinversion of Secondary Alcohols1,2-Diols. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-469970
Modern Language Association (MLA)
Meena, Vachan Singh…[et al.]. Demonstration of Redox Potential of Metschnikowia koreensis for Stereoinversion of Secondary Alcohols1,2-Diols. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-469970
American Medical Association (AMA)
Meena, Vachan Singh& Banoth, Linga& Banerjee, Uttam Chand. Demonstration of Redox Potential of Metschnikowia koreensis for Stereoinversion of Secondary Alcohols1,2-Diols. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-469970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469970