Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes
Joint Authors
Allan, Carolyn A.
Hedger, Mark P.
Chen, Yi
Wu, Michael
Wu, Hui
Phillips, David J.
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Aims.
Activins A and B, and their binding protein, follistatin, regulate glucose metabolism and inflammation.
Consequently, their role in type 2 diabetes (T2D) was examined.
Methods.
Blood was taken from fasted participants (34 males; 58 females; 50–75 years) with diabetes or during an oral glucose tolerance test (OGTT).
Clinical parameters were assessed, and blood assayed for activins, follistatin, and C-reactive protein.
Results.
Serum levels of activin A (93.3 ± 27.0 pg/mL, mean ± SD), B (81.8 ± 30.8 pg/mL), or follistatin (6.52 ± 3.15 ng/mL) were not different (P>0.05) between subjects with normal OGTT (n=39), impaired glucose tolerance and/or fasting glucose (n=17), or T2D (n=36).
However, activin A and/or activin B were positively correlated with parameters of insulin resistance and T2D, including fasting glucose (P<0.001), fasting insulin (P=0.02), glycated hemoglobin (P=0.003), and homeostasis model assessment of insulin resistance (HOMA-IR; P<0.001).
Follistatin was positively correlated with HOMA-IR alone (P=0.01).
Conclusions.
These data indicate that serum measurements of activin A, B, or follistatin cannot discriminate risk for T2D in individual patients, but the activins display a positive relationship with clinical parameters of the disease.
American Psychological Association (APA)
Wu, Hui& Wu, Michael& Chen, Yi& Allan, Carolyn A.& Phillips, David J.& Hedger, Mark P.. 2012. Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-469973
Modern Language Association (MLA)
Wu, Hui…[et al.]. Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes. Experimental Diabetes Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-469973
American Medical Association (AMA)
Wu, Hui& Wu, Michael& Chen, Yi& Allan, Carolyn A.& Phillips, David J.& Hedger, Mark P.. Correlation between Blood Activin Levels and Clinical Parameters of Type 2 Diabetes. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-469973
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-469973