Nephroprotective Effect of Ursolic Acid in a Murine Model of Gentamicin-Induced Renal Damage
Joint Authors
Teerthanath, Srinivas
Habeeba, Umma
Pai, Preethi G.
Shenoy, Jnaneshwara P.
Chamari Nawarathna, Savindika
Kulkarni, Avdhooth
Reddy C., Sudarshan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
The present study evaluates the nephroprotective effects of ursolic acid in a murine model of gentamicin induced renal damage.
Wistar albino rats of either sex, weighing 150–200 g were divided into 5 groups; normal saline, gentamicin 80 mg/kg, intraperitoneally for 8 days, ursolic acid at 2, 5, and 10 mg/kg, per oral for 8 days, ursolic acid administered 3 days prior and concurrently with gentamicin for 5 days.
Blood urea, serum creatinine, uric acid and blood urea nitrogen analyses and microscopic examination of kidney were performed.
Gentamicin treatment caused nephrotoxicity as evidenced by marked elevation in serum urea, serum uric acid, serum creatinine and blood urea nitrogen (162.33 ± 9.92 mg/dL, 3.13 ± 0.12 mg/dL, 6.85 ± 0.35 mg/dL and 75.86 ± 4.64 mg/dL; resp.) when compared to the saline treated groups.
Co-administration of ursolic acid with gentamicin decreased the rise in these parameters in a dose dependent manner.
Histopathological analysis revealed epithelial loss with intense granular degeneration in gentamicin treated rats, whereas ursolic acid mitigated the severity of gentamicin-induced renal damage.
To conclude, our data suggest that ursolic acid exhibits renoprotective effect in gentamicin induced renal damage and further studies on its mechanis of action are warranted.
American Psychological Association (APA)
Pai, Preethi G.& Chamari Nawarathna, Savindika& Kulkarni, Avdhooth& Habeeba, Umma& Reddy C., Sudarshan& Teerthanath, Srinivas…[et al.]. 2012. Nephroprotective Effect of Ursolic Acid in a Murine Model of Gentamicin-Induced Renal Damage. ISRN Pharmacology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-470001
Modern Language Association (MLA)
Pai, Preethi G.…[et al.]. Nephroprotective Effect of Ursolic Acid in a Murine Model of Gentamicin-Induced Renal Damage. ISRN Pharmacology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-470001
American Medical Association (AMA)
Pai, Preethi G.& Chamari Nawarathna, Savindika& Kulkarni, Avdhooth& Habeeba, Umma& Reddy C., Sudarshan& Teerthanath, Srinivas…[et al.]. Nephroprotective Effect of Ursolic Acid in a Murine Model of Gentamicin-Induced Renal Damage. ISRN Pharmacology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-470001
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470001