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Gait Impairment in a Rat Model of Focal Cerebral Ischemia
Joint Authors
Parkkinen, Saara
Tarkka, Ina
Huttunen, Joanna
Ortega, Francisco J.
Kuptsova, Kristina
Jolkkonen, Jukka
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The availability of proper tests for gait evaluation following cerebral ischemia in rats has been limited.
The automated, quantitative CatWalk system, which was initially designed to measure gait in models of spinal cord injury, neuropathic pain, and peripheral nerve injury, is said to be a useful tool for the study of motor impairment in stroke animals.
Here we report our experiences of using CatWalk XT with rats subjected to transient middle cerebral artery occlusion (MCAO), during their six-week followup.
Large corticostriatal infarct was confirmed by MRI in all MCAO rats, which was associated with severe sensorimotor impairment.
In contrast, the gait impairment was at most mild, which is consistent with seemingly normal locomotion of MCAO rats.
Many of the gait parameters were affected by body weight, walking speed, and motivation despite the use of a goal box.
In addition, MCAO rats showed bilateral compensation, which was developed to stabilize proper locomotion.
All of these interferences may confound the data interpretation.
Taken together, the translational applicability of CatWalk XT in evaluating motor impairment and treatment efficacy remains to be limited at least in rats with severe corticostriatal infarct and loss of body weight.
American Psychological Association (APA)
Parkkinen, Saara& Ortega, Francisco J.& Kuptsova, Kristina& Huttunen, Joanna& Tarkka, Ina& Jolkkonen, Jukka. 2013. Gait Impairment in a Rat Model of Focal Cerebral Ischemia. Stroke Research and Treatment،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-470013
Modern Language Association (MLA)
Parkkinen, Saara…[et al.]. Gait Impairment in a Rat Model of Focal Cerebral Ischemia. Stroke Research and Treatment No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-470013
American Medical Association (AMA)
Parkkinen, Saara& Ortega, Francisco J.& Kuptsova, Kristina& Huttunen, Joanna& Tarkka, Ina& Jolkkonen, Jukka. Gait Impairment in a Rat Model of Focal Cerebral Ischemia. Stroke Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-470013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470013