The Small GTPase Rap1b : A Bidirectional Regulator of Platelet Adhesion Receptors
Joint Authors
Guidetti, Gianni Francesco
Torti, Mauro
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Integrins and other families of cell adhesion receptors are responsible for platelet adhesion and aggregation, which are essential steps for physiological haemostasis, as well as for the development of thrombosis.
The modulation of platelet adhesive properties is the result of a complex pattern of inside-out and outside-in signaling pathways, in which the members of the Rap family of small GTPases are bidirectionally involved.
This paper focuses on the regulation of the main Rap GTPase expressed in circulating platelets, Rap1b, downstream of adhesion receptors, and summarizes the most recent achievements in the investigation of the function of this protein as regulator of platelet adhesion and thrombus formation.
American Psychological Association (APA)
Guidetti, Gianni Francesco& Torti, Mauro. 2012. The Small GTPase Rap1b : A Bidirectional Regulator of Platelet Adhesion Receptors. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-470028
Modern Language Association (MLA)
Guidetti, Gianni Francesco& Torti, Mauro. The Small GTPase Rap1b : A Bidirectional Regulator of Platelet Adhesion Receptors. Journal of Signal Transduction No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-470028
American Medical Association (AMA)
Guidetti, Gianni Francesco& Torti, Mauro. The Small GTPase Rap1b : A Bidirectional Regulator of Platelet Adhesion Receptors. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-470028
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470028