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Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis : As a Model of Crohn's Disease
Joint Authors
Reedtz-Runge, Stine
Poulsen, Steen Seier
Markholst, Helle
Lindebo Holm, Thomas
Source
International Journal of Inflammation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Animal models are important tools in the development of new drug candidates against the inflammatory bowel diseases (IBDs) Crohn's disease and ulcerative colitis.
In order to increase the translational value of these models, it is important to increase knowledge relating to standard drugs.
Using the SCID adoptive transfer colitis model, we have evaluated the effect of currently used IBD drugs and IBD drug candidates, that is, anti-TNF-α, TNFR-Fc, anti-IL-12p40, anti-IL-6, CTLA4-Ig, anti-α4β7 integrin, enrofloxacin/metronidazole, and cyclosporine.
We found that anti-TNF-α, antibiotics, anti-IL-12p40, anti-α4β7 integrin, CTLA4-Ig, and anti-IL-6 effectively prevented onset of colitis, whereas TNFR-Fc and cyclosporine did not.
In intervention studies, antibiotics, anti-IL-12p40, and CTLA4-Ig induced remission, whereas the other compounds did not.
The data suggest that the adoptive transfer model and the inflammatory bowel diseases have some main inflammatory pathways in common.
The finding that some well-established IBD therapeutics do not have any effect in the model highlights important differences between the experimental model and the human disease.
American Psychological Association (APA)
Lindebo Holm, Thomas& Poulsen, Steen Seier& Markholst, Helle& Reedtz-Runge, Stine. 2012. Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis : As a Model of Crohn's Disease. International Journal of Inflammation،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-470040
Modern Language Association (MLA)
Lindebo Holm, Thomas…[et al.]. Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis : As a Model of Crohn's Disease. International Journal of Inflammation No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-470040
American Medical Association (AMA)
Lindebo Holm, Thomas& Poulsen, Steen Seier& Markholst, Helle& Reedtz-Runge, Stine. Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis : As a Model of Crohn's Disease. International Journal of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-470040
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470040