Phase II Study of Temozolomide and Thalidomide in Patients with Unresectable or Metastatic Leiomyosarcoma
Joint Authors
Hesdorffer, Mary
Keohan, Mary Louise
Jin, Zhezhen
Boyar, Michelle S.
Taub, Robert N.
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-11-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We assessed the efficacy of combined temozolomide and thalidomide in patients with unresectable or metastatic leiomyosarcoma in a phase II single-institution trial.
Twenty-four patients were enrolled.
Temozolomide (150 mg/m2/day for 7 days every other week) was administered with concomitant thalidomide (200 mg/day), and continued until unacceptable toxicity or disease progression.
There were no complete responses and two (10%) partial responses.
Five patients (24%) had stable disease for at least six months.
Fourteen patients (67%) progressed after a median of two-month treatment.
The median overall survival (twenty-two assessable patients) was 9.5 months [95% CI 7–28 months].
There were no treatment-related deaths or CTC grade 4 toxicities.
Thirteen patients were dose-reduced or discontinued thalidomide due to toxicity.
In conclusion, this combination of temozolomide and thalidomide provided disease stabilization in a subset of patients with advanced leiomyosarcoma.
We hypothesize that temozolomide is the active agent in this regimen, and should be further studied.
American Psychological Association (APA)
Boyar, Michelle S.& Hesdorffer, Mary& Keohan, Mary Louise& Jin, Zhezhen& Taub, Robert N.. 2008. Phase II Study of Temozolomide and Thalidomide in Patients with Unresectable or Metastatic Leiomyosarcoma. Sarcoma،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-470062
Modern Language Association (MLA)
Boyar, Michelle S.…[et al.]. Phase II Study of Temozolomide and Thalidomide in Patients with Unresectable or Metastatic Leiomyosarcoma. Sarcoma No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-470062
American Medical Association (AMA)
Boyar, Michelle S.& Hesdorffer, Mary& Keohan, Mary Louise& Jin, Zhezhen& Taub, Robert N.. Phase II Study of Temozolomide and Thalidomide in Patients with Unresectable or Metastatic Leiomyosarcoma. Sarcoma. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-470062
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470062