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Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors
Joint Authors
Gaudette, Frédéric
Besterman, Jeffrey M.
Wang, James
Beaulieu, Normand
Nguyen, Hannah
Maroun, Christiane
Vaisburg, Arkadii
Raeppel, Stéphane L.
Source
International Journal of Medicinal Chemistry
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-02
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A novel series of N-(3-(6-substituted-aminopyridin-3-yloxy)phenyl)-2-oxo-3-phenylimidazolidine-1-carboxamides targeting TrkA receptor tyrosine kinase was identified.
SAR study of the series allowed us to design and synthesize compounds possessing inhibitory activity of TrkA kinase enzyme in the low nanomolar range with low residual activity against c-Met and with no significant activity against VEGFR2.
American Psychological Association (APA)
Raeppel, Stéphane L.& Gaudette, Frédéric& Nguyen, Hannah& Beaulieu, Normand& Wang, James& Maroun, Christiane…[et al.]. 2012. Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors. International Journal of Medicinal Chemistry،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-470080
Modern Language Association (MLA)
Raeppel, Stéphane L.…[et al.]. Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors. International Journal of Medicinal Chemistry No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-470080
American Medical Association (AMA)
Raeppel, Stéphane L.& Gaudette, Frédéric& Nguyen, Hannah& Beaulieu, Normand& Wang, James& Maroun, Christiane…[et al.]. Identification of a Novel Series of Potent TrkA Receptor Tyrosine Kinase Inhibitors. International Journal of Medicinal Chemistry. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-470080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470080