Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection
Joint Authors
Ji, Shuming
Li, Xue
Wen, Jiqiu
Chen, Jinsong
Liu, Zhihong
Sun, Qiquan
Cheng, Dongrei
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Differentiating BK virus nephropathy (BKVN) from acute rejection (AR) is crucial in clinical practice, as both of them have interstitial inflammation in the grafts.
The purpose of the study is to describe the inflammatory cellular constituents of BKVN and to determine the clinical utility of immunophenotyping findings in distinguishing BKVN from AR.
In addition, the expression of the HLA-DR was investigated.
Sixty-five renal allograft recipients were included in this study, including 22 cases of BKVN, 31 cases of AR, and 12 cases of stable allograft.
Immunostaining for infiltrating lymphocytes showed that the number of CD20 cells (P<0.001) and the percentages of CD3 (P<0.001), CD4 (P=0.004), CD8 (P=0.005), and CD20 (P=0.002) cells were all significantly different between BKVN and AR.
Moreover, there were no statistically significant differences in tubule cell HLA-DR expression (P=0.156).
This observation suggests that the number of CD20 cells and the percentages of CD3, CD4, CD8, and CD20 cells in renal biopsies would aid the distinction between BKVN and AR.
On the other hand, the presence of HLA-DR upregulation may not only be specific for acute rejection but also be a response to BKVN.
American Psychological Association (APA)
Li, Xue& Sun, Qiquan& Chen, Jinsong& Ji, Shuming& Wen, Jiqiu& Cheng, Dongrei…[et al.]. 2013. Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470118
Modern Language Association (MLA)
Li, Xue…[et al.]. Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection. Clinical and Developmental Immunology No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-470118
American Medical Association (AMA)
Li, Xue& Sun, Qiquan& Chen, Jinsong& Ji, Shuming& Wen, Jiqiu& Cheng, Dongrei…[et al.]. Immunophenotyping in BK Virus Allograft Nephropathy Distinct from Acute Rejection. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-470118
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470118