Biomolecular Markers in Cancer of the Tongue
Joint Authors
Paolo, Foa
Fiore, Jessica
Codecà, Carla
Ferrari, Daris
Moneghini, Laura
Bosari, Silvano
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The incidence of tongue cancer is increasing worldwide, and its aggressiveness remains high regardless of treatment.
Genetic changes and the expression of abnormal proteins have been frequently reported in the case of head and neck cancers, but the little information that has been published concerning tongue tumours is often contradictory.
This review will concentrate on the immunohistochemical expression of biomolecular markers and their relationships with clinical behaviour and prognosis.
Most of these proteins are associated with nodal stage, tumour progression and metastases, but there is still controversy concerning their impact on disease-free and overall survival, and treatment response.
More extensive clinical studies are needed to identify the patterns of molecular alterations and the most reliable predictors in order to develop tailored anti-tumour strategies based on the targeting of hypoxia markers, vascular and lymphangiogenic factors, epidermal growth factor receptors, intracytoplasmatic signalling and apoptosis.
American Psychological Association (APA)
Ferrari, Daris& Codecà, Carla& Fiore, Jessica& Moneghini, Laura& Bosari, Silvano& Paolo, Foa. 2009. Biomolecular Markers in Cancer of the Tongue. Journal of Oncology،Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-470119
Modern Language Association (MLA)
Ferrari, Daris…[et al.]. Biomolecular Markers in Cancer of the Tongue. Journal of Oncology No. 2009 (2009), pp.1-11.
https://search.emarefa.net/detail/BIM-470119
American Medical Association (AMA)
Ferrari, Daris& Codecà, Carla& Fiore, Jessica& Moneghini, Laura& Bosari, Silvano& Paolo, Foa. Biomolecular Markers in Cancer of the Tongue. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-11.
https://search.emarefa.net/detail/BIM-470119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470119