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Hsp90 as a Gatekeeper of Tumor Angiogenesis : Clinical Promise and Potential Pitfalls
Joint Authors
Isaacs, J. S.
Bohonowych, J. E.
Gopal, U.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-24
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Tumor vascularization is an essential modulator of early tumor growth, progression, and therapeutic outcome.
Although antiangiogenic treatments appear promising, intrinsic and acquired tumor resistance contributes to treatment failure.
Clinical inhibition of the molecular chaperone heat shock protein 90 (Hsp90) provides an opportunity to target multiple aspects of this signaling resiliency, which may elicit more robust and enduring tumor repression relative to effects elicited by specifically targeted agents.
This review highlights several primary effectors of angiogenesis modulated by Hsp90 and describes the clinical challenges posed by the redundant circuitry of these pathways.
The four main topics addressed include (1) Hsp90-mediated regulation of HIF/VEGF signaling, (2) chaperone-dependent regulation of HIF-independent VEGF-mediated angiogenesis, (3) Hsp90-dependent targeting of key proangiogenic receptor tyrosine kinases and modulation of drug resistance, and (4) consideration of factors such as tumor microenvironment that pose several challenges for the clinical efficacy of anti-angiogenic therapy and Hsp90-targeted strategies.
American Psychological Association (APA)
Bohonowych, J. E.& Gopal, U.& Isaacs, J. S.. 2010. Hsp90 as a Gatekeeper of Tumor Angiogenesis : Clinical Promise and Potential Pitfalls. Journal of Oncology،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-470127
Modern Language Association (MLA)
Bohonowych, J. E.…[et al.]. Hsp90 as a Gatekeeper of Tumor Angiogenesis : Clinical Promise and Potential Pitfalls. Journal of Oncology No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-470127
American Medical Association (AMA)
Bohonowych, J. E.& Gopal, U.& Isaacs, J. S.. Hsp90 as a Gatekeeper of Tumor Angiogenesis : Clinical Promise and Potential Pitfalls. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-470127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470127