Peripheral Nerve Repair with Cultured Schwann Cells : Getting Closer to the Clinics
Joint Authors
Borlongan, Cesario V.
Rodrigues, Maria Carolina O.
Voltarelli, Julio Cesar
Glover, Loren E.
Rodrigues, Antonio Antunes
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
Peripheral nerve injuries are a frequent and disabling condition, which affects 13 to 23 per 100.000 persons each year.
Severe cases, with structural disruption of the nerve, are associated with poor functional recovery.
The experimental treatment using nerve grafts to replace damaged or shortened axons is limited by technical difficulties, invasiveness, and mediocre results.
Other therapeutic choices include the adjunctive application of cultured Schwann cells and nerve conduits to guide axonal growth.
The bone marrow is a rich source of mesenchymal cells, which can be differentiated in vitro into Schwann cells and subsequently engrafted into the damaged nerve.
Alternatively, undifferentiated bone marrow mesenchymal cells can be associated with nerve conduits and afterward transplanted.
Experimental studies provide evidence of functional, histological, and electromyographical improvement following transplantation of bone-marrow-derived cells in animal models of peripheral nerve injury.
This paper focuses on this new therapeutic approach highlighting its direct translational and clinical utility in promoting regeneration of not only acute but perhaps also chronic cases of peripheral nerve damage.
American Psychological Association (APA)
Rodrigues, Maria Carolina O.& Rodrigues, Antonio Antunes& Glover, Loren E.& Voltarelli, Julio Cesar& Borlongan, Cesario V.. 2012. Peripheral Nerve Repair with Cultured Schwann Cells : Getting Closer to the Clinics. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-470141
Modern Language Association (MLA)
Rodrigues, Maria Carolina O.…[et al.]. Peripheral Nerve Repair with Cultured Schwann Cells : Getting Closer to the Clinics. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-470141
American Medical Association (AMA)
Rodrigues, Maria Carolina O.& Rodrigues, Antonio Antunes& Glover, Loren E.& Voltarelli, Julio Cesar& Borlongan, Cesario V.. Peripheral Nerve Repair with Cultured Schwann Cells : Getting Closer to the Clinics. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-470141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470141