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Nonsteroidal Anti-Inflammatory Drugs for Wounds : Pain Relief or Excessive Scar Formation?
Joint Authors
Wang, Peng-Hui
Su, Wen-Hsiang
Tsou, Tsung-Shan
Chen, Chien-Sheng
Cheng, Ming-Huei
Chang, Wen-Hsun
Lee, Wen-Ling
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The inflammatory process has direct effects on normal and abnormal wound healing.
Hypertrophic scar formation is an aberrant form of wound healing and is an indication of an exaggerated function of fibroblasts and excess accumulation of extracellular matrix during wound healing.
Two cytokines—transforming growth factor-β (TGF-β) and prostaglandin E2 (PGE2)—are lipid mediators of inflammation involving wound healing.
Overproduction of TGF-β and suppression of PGE2 are found in excessive wound scarring compared with normal wound healing.
Nonsteroidal anti-inflammatory drugs (NSAIDs) or their selective cyclooxygenase-2 (COX-2) inhibitors are frequently used as a pain-killer.
However, both NSAIDs and COX-2 inhibitors inhibit PGE2 production, which might exacerbate excessive scar formation, especially when used during the later proliferative phase.
Therefore, a balance between cytokines and medication in the pathogenesis of wound healing is needed.
This report is a literature review pertaining to wound healing and is focused on TGF-β and PGE2.
American Psychological Association (APA)
Su, Wen-Hsiang& Cheng, Ming-Huei& Lee, Wen-Ling& Tsou, Tsung-Shan& Chang, Wen-Hsun& Chen, Chien-Sheng…[et al.]. 2010. Nonsteroidal Anti-Inflammatory Drugs for Wounds : Pain Relief or Excessive Scar Formation?. Mediators of Inflammation،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-470155
Modern Language Association (MLA)
Su, Wen-Hsiang…[et al.]. Nonsteroidal Anti-Inflammatory Drugs for Wounds : Pain Relief or Excessive Scar Formation?. Mediators of Inflammation No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-470155
American Medical Association (AMA)
Su, Wen-Hsiang& Cheng, Ming-Huei& Lee, Wen-Ling& Tsou, Tsung-Shan& Chang, Wen-Hsun& Chen, Chien-Sheng…[et al.]. Nonsteroidal Anti-Inflammatory Drugs for Wounds : Pain Relief or Excessive Scar Formation?. Mediators of Inflammation. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-470155
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470155