Salivary Protein Profiles among HER2neu-Receptor-Positive and -Negative Breast Cancer Patients : Support for Using Salivary Protein Profiles for Modeling Breast Cancer Progression
Joint Authors
Streckfus, Charles Frederick
Edwards, Cynthia
Bigler, Lenora
Arreola, Daniel
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
The objective of this study was to compare the salivary protein profiles from individuals diagnosed with breast cancer that were either HER2/neu receptor positive or negative.
Methods.
Two pooled saliva specimens underwent proteomic analysis.
One pooled specimen was from women diagnosed with stage IIa HER2/neu-receptor-positive breast cancer patients (n=10) and the other was from women diagnosed with stage IIa HER2/neu-receptor-negative cancer patients (n=10).
The pooled samples were trypsinized and the peptides labeled with iTRAQ reagent.
Specimens were analyzed using an LC-MS/MS mass spectrometer.
Results.
The results yielded approximately 71 differentially expressed proteins in the saliva specimens.
There were 34 upregulated proteins and 37 downregulated proteins.
American Psychological Association (APA)
Streckfus, Charles Frederick& Arreola, Daniel& Edwards, Cynthia& Bigler, Lenora. 2012. Salivary Protein Profiles among HER2neu-Receptor-Positive and -Negative Breast Cancer Patients : Support for Using Salivary Protein Profiles for Modeling Breast Cancer Progression. Journal of Oncology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-470157
Modern Language Association (MLA)
Streckfus, Charles Frederick…[et al.]. Salivary Protein Profiles among HER2neu-Receptor-Positive and -Negative Breast Cancer Patients : Support for Using Salivary Protein Profiles for Modeling Breast Cancer Progression. Journal of Oncology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-470157
American Medical Association (AMA)
Streckfus, Charles Frederick& Arreola, Daniel& Edwards, Cynthia& Bigler, Lenora. Salivary Protein Profiles among HER2neu-Receptor-Positive and -Negative Breast Cancer Patients : Support for Using Salivary Protein Profiles for Modeling Breast Cancer Progression. Journal of Oncology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-470157
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470157
