Pinellia ternata, Citrus reticulata, and Their Combinational Prescription Inhibit Eosinophil Infiltration and Airway Hyperresponsiveness by Suppressing CCR3+ and Th2 Cytokines Production in the Ovalbumin-Induced Asthma Model
Joint Authors
Kim, Seung-Hyung
Kim, Bok-Kyu
Ok, In-Soo
Lee, Young-Cheol
Lee, Jang-Cheon
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background and Objective.
This study was aimed to analyse the curative effects of Pinellia ternata, Citrus reticulata, and their combination on airway hyperresponsiveness (AHR) to inhaled methacholine, pulmonary eosinophilic infiltration, Th2 cytokine production, and IgE and histamine production in a murine model of asthma.
Methods.
For this purpose, BALB/c mice were systemically sensitized to ovalbumin (OVA) followed intratracheally, intraperitoneally, and by aerosol allergen challenges for 12 weeks.
We examined the development of pulmonary eosinophilic accumulation, control of Th2 cytokine, immunoglobulin E (IgE), and histamine productions in a murine model of asthma.
Results.
Our data suggest that the therapeutic mechanism by which Pinellia ternata, Citrus reticulata, and their combinational prescription effectively treats asthma is based on reductions of eosinophil infiltration, eotaxin receptor (CCR3), histamine, OVA-specific IgE productions in serum, and Th2 cytokines (IL-5, IL-13) by marked reductions of IL-5 and IL-13 mRNA expression in lung tissue.
Conclusions.
These findings provide evidence that Pinellia ternata, Citrus reticulata, and their combination play a regulatory role in allergic inflammation and offer therapeutic approaches as novel CCR3 antagonists for treatment asthma.
However, it is not clear whether pharmacological activities of prescription composed of two herbs are potentiated due to synergistic effect or additive effect.
American Psychological Association (APA)
Ok, In-Soo& Kim, Seung-Hyung& Kim, Bok-Kyu& Lee, Jang-Cheon& Lee, Young-Cheol. 2009. Pinellia ternata, Citrus reticulata, and Their Combinational Prescription Inhibit Eosinophil Infiltration and Airway Hyperresponsiveness by Suppressing CCR3+ and Th2 Cytokines Production in the Ovalbumin-Induced Asthma Model. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-470160
Modern Language Association (MLA)
Ok, In-Soo…[et al.]. Pinellia ternata, Citrus reticulata, and Their Combinational Prescription Inhibit Eosinophil Infiltration and Airway Hyperresponsiveness by Suppressing CCR3+ and Th2 Cytokines Production in the Ovalbumin-Induced Asthma Model. Mediators of Inflammation No. 2009 (2009), pp.1-10.
https://search.emarefa.net/detail/BIM-470160
American Medical Association (AMA)
Ok, In-Soo& Kim, Seung-Hyung& Kim, Bok-Kyu& Lee, Jang-Cheon& Lee, Young-Cheol. Pinellia ternata, Citrus reticulata, and Their Combinational Prescription Inhibit Eosinophil Infiltration and Airway Hyperresponsiveness by Suppressing CCR3+ and Th2 Cytokines Production in the Ovalbumin-Induced Asthma Model. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-10.
https://search.emarefa.net/detail/BIM-470160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470160