Measurement of Weight in Clinical Trials : Is One Day Enough?
Joint Authors
Appel, Lawrence J.
Loria, Catherine M.
Jerome, Gerald J.
Maruthur, Nisa M.
Clark, Jeanne M.
Lien, Lillian F.
Vollmer, William M.
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-04
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Background.
Weight is typically measured on a single day in research studies.
This practice assumes negligible day-to-day weight variability, although little evidence exists to support this assumption.
We compared the precision of measuring weight on one versus two days among control participants in the Weight Loss Maintenance trial.
Methods.
Trained staff measured weight on two separate days at baseline, 12 months, and 30 months (2004–2007).
We calculated the standard deviation (SD) of mean weight change from baseline to the 12- and 30-month visits using (a) the first and (b) both daily weights from each visit and conducted a variance components analysis (2009).
Results.
Of the 316 participants with follow-up measurements, mean (SD) age was 55.8 (8.5) years, BMI was 30.8 (4.5) kg/m2, 64% were women, 36% were black, and 50% were obese.
At 12 months, the SD of mean weight change was 5.1 versus 5.0 kg using one versus two days of weight measurements (P=.76), while at 30 months the corresponding SDs were 6.3 and 6.3 kg (P=.98).
We observed similar findings within subgroups of BMI, sex, and race.
Day-to-day variability within individuals accounted for <1% of variability in weight.
Conclusions.
Measurement of weight on two separate days has no advantage over measurement on a single day in studies with well-standardized weight measurement protocols.
American Psychological Association (APA)
Maruthur, Nisa M.& Vollmer, William M.& Clark, Jeanne M.& Jerome, Gerald J.& Lien, Lillian F.& Loria, Catherine M.…[et al.]. 2010. Measurement of Weight in Clinical Trials : Is One Day Enough?. Journal of Obesity،Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-470163
Modern Language Association (MLA)
Maruthur, Nisa M.…[et al.]. Measurement of Weight in Clinical Trials : Is One Day Enough?. Journal of Obesity No. 2010 (2010), pp.1-3.
https://search.emarefa.net/detail/BIM-470163
American Medical Association (AMA)
Maruthur, Nisa M.& Vollmer, William M.& Clark, Jeanne M.& Jerome, Gerald J.& Lien, Lillian F.& Loria, Catherine M.…[et al.]. Measurement of Weight in Clinical Trials : Is One Day Enough?. Journal of Obesity. 2010. Vol. 2010, no. 2010, pp.1-3.
https://search.emarefa.net/detail/BIM-470163
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470163