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Neoadjuvant Chemoradiation in Squamous Cell Carcinoma of the Maxillary Sinus : A 26-Year Experience
Joint Authors
Kreppel, Matthias
Zöller, Joachim E.
Eich, Hans Theodor
Beutner, Dirk
Guntinas-Lichius, Orlando
Lüers, Jan Christoffer
Danscheid, Sarah
Scheer, Martin
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The aim of our study was to evaluate the effects of neoadjuvant platinum-based radiochemotherapy (RCT) in patients with maxillary sinus squamous cell carcinoma and to compare the results with other multimodality treatment concepts for advanced-stage maxillary sinus carcinoma in the literature.
Methods.
In total, 53 patients with squamous cell carcinoma of the maxillary sinus were reviewed retrospectively.
All patients received a neoadjuvant RCT containing either cisplatin or carboplatin followed by radical surgery.
Overall survival and locoregional control were plotted by Kaplan-Meier analysis.
Prognostic factors were identified through univariate and multivariate analysis.
Results.
Five-year overall survival for all patients was 35%.
Eleven patients achieved a complete response after radiochemotherapy.
The complete response rate was significantly higher for patients treated with cisplatin (P=0.028); however the 5-year overall survival rates did not differ significantly (P=0.673) for patients treated with cisplatin (37%) and carboplatin (32%).
Orbital invasion (P=0.005) and complete response to radiochemotherapy (P=0.021) had a significant impact on overall survival in univariate analysis.
Conclusions.
Neoadjuvant radiochemotherapy followed by radical surgery is an effective treatment for patients with advanced maxillary sinus squamous cell carcinoma.
In terms of treatment response cisplatin seems to be more effective than carboplatin.
American Psychological Association (APA)
Kreppel, Matthias& Danscheid, Sarah& Scheer, Martin& Lüers, Jan Christoffer& Eich, Hans Theodor& Zöller, Joachim E.…[et al.]. 2012. Neoadjuvant Chemoradiation in Squamous Cell Carcinoma of the Maxillary Sinus : A 26-Year Experience. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470182
Modern Language Association (MLA)
Kreppel, Matthias…[et al.]. Neoadjuvant Chemoradiation in Squamous Cell Carcinoma of the Maxillary Sinus : A 26-Year Experience. Chemotherapy Research and Practice No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-470182
American Medical Association (AMA)
Kreppel, Matthias& Danscheid, Sarah& Scheer, Martin& Lüers, Jan Christoffer& Eich, Hans Theodor& Zöller, Joachim E.…[et al.]. Neoadjuvant Chemoradiation in Squamous Cell Carcinoma of the Maxillary Sinus : A 26-Year Experience. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470182