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Genotype-Related Effect of Crowding Stress on Blood Pressure and Vascular Function in Young Female Rats
Joint Authors
Majzunova, Miroslava
Sestakova, Natalia
Kluknavsky, Michal
Dovinová, Ima
Bernatova, Iveta
Slezak, Peter
Puzserova, Angelika
Balis, Peter
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study investigated the influence of chronic crowding stress on nitric oxide (NO) production, vascular function and oxidative status in young Wistar-Kyoto (WKY), borderline hypertensive (BHR) and spontaneously hypertensive (SHR) female rats.
Five-week old rats were exposed to crowding for two weeks.
Crowding elevated plasma corticosterone (P<0.05) and accelerated BP (P<0.01 versus basal) only in BHR.
NO production and superoxide concentration were significantly higher in the aortas of control BHR and SHR versus WKY.
Total acetylcholine (ACh)-induced relaxation in the femoral artery was reduced in control SHR versus WKY and BHR, and stress did not affect it significantly in any genotype.
The attenuation of ACh-induced relaxation in SHR versus WKY was associated with reduction of its NO-independent component.
Crowding elevated NO production in all strains investigated but superoxide concentration was increased only in WKY, which resulted in reduced NO-dependent relaxation in WKY.
In crowded BHR and SHR, superoxide concentration was either unchanged or reduced, respectively, but NO-dependent relaxation was unchanged in both BHR and SHR versus their respective control group.
This study points to genotype-related differences in stress vulnerability in young female rats.
The most pronounced negative influence of stress was observed in BHR despite preserved endothelial function.
American Psychological Association (APA)
Slezak, Peter& Puzserova, Angelika& Balis, Peter& Sestakova, Natalia& Majzunova, Miroslava& Dovinová, Ima…[et al.]. 2014. Genotype-Related Effect of Crowding Stress on Blood Pressure and Vascular Function in Young Female Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-470186
Modern Language Association (MLA)
Slezak, Peter…[et al.]. Genotype-Related Effect of Crowding Stress on Blood Pressure and Vascular Function in Young Female Rats. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-470186
American Medical Association (AMA)
Slezak, Peter& Puzserova, Angelika& Balis, Peter& Sestakova, Natalia& Majzunova, Miroslava& Dovinová, Ima…[et al.]. Genotype-Related Effect of Crowding Stress on Blood Pressure and Vascular Function in Young Female Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-470186
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470186