Technetium-99m-Labeled Autologous Serum Albumin : A Personal-Exclusive Source of Serum Component
Joint Authors
Li, Dian-Kun
Chen, Yi-Chun
Chuang, Mei-Hua
Wang, Yuh-Feng
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Technetium-99m human serum albumin (99mTc-HSA) is an important radiopharmaceutical required in nuclear medicine studies.
However, the risk of transfusion-transmitted infection remains a major safety concern.
Autopreparation of serum component acquired from patient provides a “personal-exclusive” source for radiolabeling.
This paper is to evaluate the practicality of on-site elusion and subsequent radiolabeling efficacy for serum albumin.
Results showed that the autologous elute contained more albumin fraction than serum without extraction procedure.
Good radiochemical purity and stability were demonstrated after radiolabeling.
Biodistribution study showed that labeled albumin accumulated immediately in the lung, liver, and kidney.
It was cleared steadily and excreted in the urine.
The biologic half-life was defined, and all samples passed the pyrogenicity and sterility tests.
In conclusion, autoalbumin could be extracted and radiolabeled properly in a nuclear medicine setting.
Moreover, the risk of transfusion-transmitted infection associated with nonautologous, multisource 99mTc-HSA agents can be reduced.
American Psychological Association (APA)
Wang, Yuh-Feng& Chen, Yi-Chun& Li, Dian-Kun& Chuang, Mei-Hua. 2011. Technetium-99m-Labeled Autologous Serum Albumin : A Personal-Exclusive Source of Serum Component. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-470207
Modern Language Association (MLA)
Wang, Yuh-Feng…[et al.]. Technetium-99m-Labeled Autologous Serum Albumin : A Personal-Exclusive Source of Serum Component. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-470207
American Medical Association (AMA)
Wang, Yuh-Feng& Chen, Yi-Chun& Li, Dian-Kun& Chuang, Mei-Hua. Technetium-99m-Labeled Autologous Serum Albumin : A Personal-Exclusive Source of Serum Component. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-470207
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470207