Amyloidosis in Alzheimer’s Disease : The Toxicity of Amyloid Beta (Aβ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy
Joint Authors
Tencomnao, Tewin
Prasansuklab, Anchalee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-15
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that leads to memory deficits and death.
While the number of individuals with AD is rising each year due to the longer life expectancy worldwide, current therapy can only somewhat relieve the symptoms of AD.
There is no proven medication to cure or prevent the disease, possibly due to a lack of knowledge regarding the molecular mechanisms underlying disease pathogenesis.
Most previous studies have accepted the “amyloid hypothesis,” in which the neuropathogenesis of AD is believed to be triggered by the accumulation of the toxic amyloid beta (Aβ) protein in the central nervous system (CNS).
Lately, knowledge that may be critical to unraveling the hidden pathogenic pathway of AD has been revealed.
This review concentrates on the toxicity of Aβ and the mechanism of accumulation of this toxic protein in the brain of individuals with AD and also summarizes recent advances in the study of these accumulation mechanisms together with the role of herbal medicines that could facilitate the development of more effective therapeutic and preventive strategies.
American Psychological Association (APA)
Prasansuklab, Anchalee& Tencomnao, Tewin. 2013. Amyloidosis in Alzheimer’s Disease : The Toxicity of Amyloid Beta (Aβ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-470208
Modern Language Association (MLA)
Prasansuklab, Anchalee& Tencomnao, Tewin. Amyloidosis in Alzheimer’s Disease : The Toxicity of Amyloid Beta (Aβ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-470208
American Medical Association (AMA)
Prasansuklab, Anchalee& Tencomnao, Tewin. Amyloidosis in Alzheimer’s Disease : The Toxicity of Amyloid Beta (Aβ), Mechanisms of Its Accumulation and Implications of Medicinal Plants for Therapy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-470208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470208