Refractory Scedosporium apiospermum Keratitis Successfully Treated with Combination of Amphotericin B and Voriconazole
Joint Authors
Ibrahim, Mohtar
Siti-Raihan, Ishak
Mohd-Tahir, Fadzillah
Source
Case Reports in Ophthalmological Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-20
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Aim.
To report a case of refractory fungal keratitis caused by Scedosporium apiospermum.
Methods.
Interventional case report.
Results.
A 47-year-old Malay housewife presented with left eye cornea ulcer as her first presentation of diabetes mellitus.
There was no history of ocular trauma, contact lens used, or cornea foreign body.
Scedosporium apiospermum was isolated from the cornea scrapping.
Her cornea ulcer initially responded well to topical Amphotericin B within 3 days but subsequently worsened.
Repeat cornea scrapping also yields Scedosporium apiospermum.
This refractory keratitis was successfully treated with a combination of topical Amphotericin B and Voriconazole over 6 weeks.
Conclusion.
Scedosporium apiospermum keratitis is an opportunistic infection, which is difficult to treat despite tight control of diabetes mellitus and intensive antifungal treatment.
The infection appeared to have very quick onset but needed long duration of treatment to completely heal.
Surgical debridement always plays an important role as a therapeutic procedure as well as establishes the diagnosis through repeat scrapping.
American Psychological Association (APA)
Mohd-Tahir, Fadzillah& Siti-Raihan, Ishak& Ibrahim, Mohtar. 2013. Refractory Scedosporium apiospermum Keratitis Successfully Treated with Combination of Amphotericin B and Voriconazole. Case Reports in Ophthalmological Medicine،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-470226
Modern Language Association (MLA)
Mohd-Tahir, Fadzillah…[et al.]. Refractory Scedosporium apiospermum Keratitis Successfully Treated with Combination of Amphotericin B and Voriconazole. Case Reports in Ophthalmological Medicine No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-470226
American Medical Association (AMA)
Mohd-Tahir, Fadzillah& Siti-Raihan, Ishak& Ibrahim, Mohtar. Refractory Scedosporium apiospermum Keratitis Successfully Treated with Combination of Amphotericin B and Voriconazole. Case Reports in Ophthalmological Medicine. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-470226
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470226