Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney
Joint Authors
Pinheiro, Sergio Veloso Brant
Simões e Silva, Ana Cristina
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In the past few years the understanding of the renin-angiotensin system (RAS) has improved, helping to better define the role of this system in physiological conditions and in human diseases.
Besides Angiotensin (Ang) II, the biological importance of other Ang fragments was progressively evidenced.
In this regard, Angiotensin- (Ang-) (1-7) was recognized as a biologically active product of the RAS cascade with a specific receptor, the G-protein-coupled receptor Mas, and that is mainly formed by the action of the angiotensin-converting enzyme (ACE) homolog enzyme, ACE2, which converts Ang II into Ang-(1-7).
Taking into account the biological effects of these two mediators, Ang II and Ang-(1-7), the RAS can be envisioned as a dual function system in which the vasoconstrictor/proliferative or vasodilator/antiproliferative actions are primarily driven by the balance between Ang II and Ang-(1-7), respectively.
In this paper, we will discuss our current understanding of the ACE2/Ang-(1-7)/Mas axis of the RAS in renal physiology and in the pathogenesis of primary hypertension and chronic kidney disease.
American Psychological Association (APA)
Pinheiro, Sergio Veloso Brant& Simões e Silva, Ana Cristina. 2012. Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470245
Modern Language Association (MLA)
Pinheiro, Sergio Veloso Brant& Simões e Silva, Ana Cristina. Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney. International Journal of Hypertension No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-470245
American Medical Association (AMA)
Pinheiro, Sergio Veloso Brant& Simões e Silva, Ana Cristina. Angiotensin Converting Enzyme 2, Angiotensin-(1-7), and Receptor Mas Axis in the Kidney. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-470245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-470245